PURPOSE: To identify potential biomarkers of the renal impairment in lupus nephritis using a multi-parametric renal quantitative MRI (qMRI) protocol including diffusion weighted imaging (DWI), blood oxygen level dependent (BOLD), arterial spin labeling (ASL) and T1rho MRI between a cohort of healthy volunteers and lupus nephritis (LN) patients. MATERIALS AND METHODS: The renal qMRI protocol was performed twice with repositioning in between on 10 LN patients and 10 matched controls at 1.5 T. Navigator-gated and breath-hold acquisitions followed by non-rigid image registration were used to control respiratory motion. The repeatability of the 4 MRI modalities was evaluated with the intra-class correlation coefficient (ICC) and within-subject coefficient of variation (wsCV). Unpaired t-test and stepwise logistic regression were carried out to evaluate qMRI parameters between the LN and control groups. RESULTS: The reproducibility of the 4 qMRI modalities ranged from moderate to good (ICC=0.4-0.91, wsCV≤12%) with a few exceptions. T1rho MRI and ASL renal blood flow (RBF) demonstrated significant differences between the LN and control groups. Stepwise logistic regression yielded only one significant parameter (medullar T1rho) in differentiating LN from control groups with 95% accuracy. CONCLUSION: A reasonable degree of test-retest repeatability and accuracy of a multi-parametric renal qMRI protocol has been demonstrated in healthy volunteers and LN subjects. T1rho and ASL RBF are promising imaging biomarkers of LN.
PURPOSE: To identify potential biomarkers of the renal impairment in lupus nephritis using a multi-parametric renal quantitative MRI (qMRI) protocol including diffusion weighted imaging (DWI), blood oxygen level dependent (BOLD), arterial spin labeling (ASL) and T1rho MRI between a cohort of healthy volunteers and lupus nephritis (LN) patients. MATERIALS AND METHODS: The renal qMRI protocol was performed twice with repositioning in between on 10 LN patients and 10 matched controls at 1.5 T. Navigator-gated and breath-hold acquisitions followed by non-rigid image registration were used to control respiratory motion. The repeatability of the 4 MRI modalities was evaluated with the intra-class correlation coefficient (ICC) and within-subject coefficient of variation (wsCV). Unpaired t-test and stepwise logistic regression were carried out to evaluate qMRI parameters between the LN and control groups. RESULTS: The reproducibility of the 4 qMRI modalities ranged from moderate to good (ICC=0.4-0.91, wsCV≤12%) with a few exceptions. T1rho MRI and ASL renal blood flow (RBF) demonstrated significant differences between the LN and control groups. Stepwise logistic regression yielded only one significant parameter (medullar T1rho) in differentiating LN from control groups with 95% accuracy. CONCLUSION: A reasonable degree of test-retest repeatability and accuracy of a multi-parametric renal qMRI protocol has been demonstrated in healthy volunteers and LN subjects. T1rho and ASL RBF are promising imaging biomarkers of LN.
Authors: Aghogho Odudu; Fabio Nery; Anita A Harteveld; Roger G Evans; Douglas Pendse; Charlotte E Buchanan; Susan T Francis; María A Fernández-Seara Journal: Nephrol Dial Transplant Date: 2018-09-01 Impact factor: 5.992
Authors: Hao Song; Dan Ruan; Wenyang Liu; V Andrew Stenger; Rolf Pohmann; Maria A Fernández-Seara; Tejas Nair; Sungkyu Jung; Jingqin Luo; Yuichi Motai; Jingfei Ma; John D Hazle; H Michael Gach Journal: Med Phys Date: 2017-02-21 Impact factor: 4.071
Authors: Mick J M van Eijs; Arjan D van Zuilen; Anneloes de Boer; Martijn Froeling; Tri Q Nguyen; Jaap A Joles; Tim Leiner; Marianne C Verhaar Journal: Front Physiol Date: 2017-05-16 Impact factor: 4.566
Authors: Fabio Nery; Charlotte E Buchanan; Anita A Harteveld; Aghogho Odudu; Octavia Bane; Eleanor F Cox; Katja Derlin; H Michael Gach; Xavier Golay; Marcel Gutberlet; Christoffer Laustsen; Alexandra Ljimani; Ananth J Madhuranthakam; Ivan Pedrosa; Pottumarthi V Prasad; Philip M Robson; Kanishka Sharma; Steven Sourbron; Manuel Taso; David L Thomas; Danny J J Wang; Jeff L Zhang; David C Alsop; Sean B Fain; Susan T Francis; María A Fernández-Seara Journal: MAGMA Date: 2019-12-12 Impact factor: 2.533