Dide den Hollander1, Ellen Kampman2, Carla M L van Herpen3. 1. Department of Medical Oncology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands. 2. Department for Health Evidence, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. 3. Department of Medical Oncology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands. Electronic address: carla.vanherpen@radboudumc.nl.
Abstract
BACKGROUND: The prevalence of overweight and obesity defined as BMI≥25kg/m(2) is increasing, also among head and neck cancer patients. It is unknown whether the presence of high BMI influences disease-related mortality, overall survival and recurrence in these patients. METHODS: We reviewed available literature using Pubmed and Web of Science. Human observational studies were included if they reported the impact of high BMI on mortality, recurrence or survival for head and neck cancer. RESULTS: Eleven full articles and two abstracts met the inclusion criteria: six prospective and seven retrospective cohort studies, which comprised 8.306 patients. Patients with higher BMI had increased overall survival and decreased disease-related mortality and recurrence rate compared with underweight and normal weight patients. Most studies were adjusted for potentially confounding variables, such as stage of disease and smoking habits. CONCLUSION: High BMI is associated with a better outcome in head and neck cancer.
BACKGROUND: The prevalence of overweight and obesity defined as BMI≥25kg/m(2) is increasing, also among head and neck cancerpatients. It is unknown whether the presence of high BMI influences disease-related mortality, overall survival and recurrence in these patients. METHODS: We reviewed available literature using Pubmed and Web of Science. Human observational studies were included if they reported the impact of high BMI on mortality, recurrence or survival for head and neck cancer. RESULTS: Eleven full articles and two abstracts met the inclusion criteria: six prospective and seven retrospective cohort studies, which comprised 8.306 patients. Patients with higher BMI had increased overall survival and decreased disease-related mortality and recurrence rate compared with underweight and normal weight patients. Most studies were adjusted for potentially confounding variables, such as stage of disease and smoking habits. CONCLUSION: High BMI is associated with a better outcome in head and neck cancer.
Authors: Ohad Ronen; K Thomas Robbins; Remco de Bree; Orlando Guntinas-Lichius; Dana M Hartl; Akihiro Homma; Avi Khafif; Luiz P Kowalski; Fernando López; Antti A Mäkitie; Wai Tong Ng; Alessandra Rinaldo; Juan P Rodrigo; Alvaro Sanabria; Alfio Ferlito Journal: Eur Arch Otorhinolaryngol Date: 2021-05-12 Impact factor: 2.503
Authors: Samantha Lang; Sarah Schimansky; Rhona Beynon; Christopher Penfold; Amy Davies; Andrea Waylen; Steven Thomas; Miranda Pring; Michael Pawlita; Tim Waterboer; Andrew R Ness Journal: Head Neck Date: 2019-01-30 Impact factor: 3.147
Authors: Mohemmed N Khan; Jack Russo; John Spivack; Christopher Pool; Ilya Likhterov; Marita Teng; Eric M Genden; Brett A Miles Journal: JAMA Otolaryngol Head Neck Surg Date: 2017-06-01 Impact factor: 6.223
Authors: Massimiliano D'Aiuto; Andrea Chirico; Michele Antonio De Riggi; Giuseppe Frasci; Michelino De Laurentiis; Maurizio Di Bonito; Patrizia Vici; Laura Pizzuti; Domenico Sergi; Marcello Maugeri-Saccà; Maddalena Barba; Antonio Giordano Journal: Cancer Biol Ther Date: 2016-03-02 Impact factor: 4.742
Authors: Marco Gallo; Valerio Adinolfi; Viola Barucca; Natalie Prinzi; Valerio Renzelli; Luigi Barrea; Paola Di Giacinto; Rosaria Maddalena Ruggeri; Franz Sesti; Emanuela Arvat; Roberto Baldelli; Emanuela Arvat; Annamaria Colao; Andrea Isidori; Andrea Lenzi; Roberto Baldell; M Albertelli; D Attala; A Bianchi; A Di Sarno; T Feola; G Mazziotti; A Nervo; C Pozza; G Puliani; P Razzore; S Ramponi; S Ricciardi; L Rizza; F Rota; E Sbardella; M C Zatelli Journal: Rev Endocr Metab Disord Date: 2020-10-06 Impact factor: 6.514
Authors: Cielito C Reyes-Gibby; Stephanie C Melkonian; Ehab Y Hanna; Sai-Ching J Yeung; Charles Lu; Mark S Chambers; Srinivas R Banala; Gary B Gunn; Sanjay S Shete Journal: Head Neck Date: 2017-03-27 Impact factor: 3.821
Authors: Kayla R Getz; Emily Bellile; Katie R Zarins; Cailey Rullman; Steven B Chinn; Jeremy M G Taylor; Laura S Rozek; Gregory T Wolf; Alison M Mondul Journal: Int J Cancer Date: 2020-12-15 Impact factor: 7.316