OBJECTIVE: Based on cross-sectional studies, sleep duration has been shown to have a relationship with the prevalence of metabolic syndrome (MS); however, no prospective studies have verified a correlation between the incidence of MS and the gender difference. Herein we prospectively determined the association between MS and gender using a large sample. METHODS: A total of 4774 subjects without MS, 30-65 years of age, participated in this study. One-way ANOVA and Chi-square test were used to analyze the baseline variables. Cox regression models were performed separately in a mixed-gender population, males and females, while controlling for lifestyle and sleep-related factors. RESULTS: During an average of 4.4-year follow-up, 1506 subjects developed MS. Both short (<6 h) and long sleep durations (8-9 and ≥9 h) increased the incidence of MS and elevated the fasting blood glucose (FBG) level in the mixed-gender population (MS: HR = 1.43, 1.25, and 1.45, respectively; elevated FBG: HR = 1.61, 1.65, and 1.98, respectively) and males (MS: HR = 1.87, 1.73, and 1.96, respectively; elevated FBG: HR = 2.27, 2.28, and 3.16, respectively). The HR(8-9 and ≥9 h) for hypertriglyceridemia in males was 1.48 and 19.4, and the HR(<6, 6-7, and ≥9 h) for hypertension in females was 1.25, 1.46, and 1.72, respectively. CONCLUSION: Both short and long sleep durations were associated with a greater incidence of MS and elevated FBG in a mixed-gender population and in males, and hypertension in females. Males who sleep longer were also at a higher risk for hypertriglyceridemia.
OBJECTIVE: Based on cross-sectional studies, sleep duration has been shown to have a relationship with the prevalence of metabolic syndrome (MS); however, no prospective studies have verified a correlation between the incidence of MS and the gender difference. Herein we prospectively determined the association between MS and gender using a large sample. METHODS: A total of 4774 subjects without MS, 30-65 years of age, participated in this study. One-way ANOVA and Chi-square test were used to analyze the baseline variables. Cox regression models were performed separately in a mixed-gender population, males and females, while controlling for lifestyle and sleep-related factors. RESULTS: During an average of 4.4-year follow-up, 1506 subjects developed MS. Both short (<6 h) and long sleep durations (8-9 and ≥9 h) increased the incidence of MS and elevated the fasting blood glucose (FBG) level in the mixed-gender population (MS: HR = 1.43, 1.25, and 1.45, respectively; elevated FBG: HR = 1.61, 1.65, and 1.98, respectively) and males (MS: HR = 1.87, 1.73, and 1.96, respectively; elevated FBG: HR = 2.27, 2.28, and 3.16, respectively). The HR(8-9 and ≥9 h) for hypertriglyceridemia in males was 1.48 and 19.4, and the HR(<6, 6-7, and ≥9 h) for hypertension in females was 1.25, 1.46, and 1.72, respectively. CONCLUSION: Both short and long sleep durations were associated with a greater incidence of MS and elevated FBG in a mixed-gender population and in males, and hypertension in females. Males who sleep longer were also at a higher risk for hypertriglyceridemia.
Authors: Marissa A Bowman; Katherine A Duggan; Ryan C Brindle; Christopher E Kline; Robert T Krafty; Julian F Thayer; Martica H Hall Journal: Sleep Med Date: 2019-02-16 Impact factor: 3.492
Authors: Marlot Kruisbrink; Wendy Robertson; Chen Ji; Michelle A Miller; Johanna M Geleijnse; Francesco P Cappuccio Journal: BMJ Open Date: 2017-12-14 Impact factor: 2.692