| Literature DB >> 26115570 |
Hiroyuki Yamazaki1, Wataru Nakayama2, Ohgi Takahashi2, Ryota Kirikoshi2, Yuta Izumikawa2, Kohei Iwasaki2, Kengo Toraiwa2, Kazuyo Ukai2, Henki Rotinsulu3, Defny S Wewengkang4, Deiske A Sumilat5, Remy E P Mangindaan5, Michio Namikoshi2.
Abstract
Two new merosesquiterpenes, verruculides A (1) and B (2), were isolated from a culture broth of the Indonesian ascidian-derived Penicillium verruculosum TPU1311, together with three known congeners, chrodrimanins A (3), B (4), and H (5). The structures of 1 and 2 were assigned on the basis of their spectroscopic data (1D and 2D NMR, HRMS, UV, CD, and IR). Compound 2 had a linear sesquiterpene moiety and was considered to be the derivative of the biosynthetic precursor for 1 and 3-5. Compounds 1, 3, and 5 inhibited the activity of protein tyrosine phosphatase 1B (PTP1B) with IC50 values of 8.4, 8.5, and 14.9 μM, respectively. Compound 2 showed 40% inhibition at 23.1 μM, while 4 was not active at 20.7 μM.Entities:
Keywords: Ascidian-derived fungus; Inhibitor; Penicillium verruculosum; Protein tyrosine phosphatase 1B; Verruculide
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Year: 2015 PMID： 26115570 DOI： 10.1016/j.bmcl.2015.06.026
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823