Literature DB >> 26114202

I2/KI-Mediated Oxidative N-N Bond Formation for the Synthesis of 1,5-Fused 1,2,4-Triazoles from N-Aryl Amidines.

Lina Song1, Xianhai Tian1, Zhigang Lv1, Ertong Li1, Jie Wu1, Yangxue Liu1, Wenquan Yu1, Junbiao Chang1,2.   

Abstract

An I2/KI-mediated oxidative N-N bond formation reaction is described. This new and environmentally benign approach allows for the convenient synthesis of a variety of 1,2,4-triazolo[1,5-a]pyridines and other 1,5-fused 1,2,4-triazoles from readily available N-aryl amidines in an efficient and scalable fashion.

Entities:  

Year:  2015        PMID： 26114202     DOI： 10.1021/acs.joc.5b01183

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  4 in total

1.  Electrochemical Strategy for Hydrazine Synthesis: Development and Overpotential Analysis of Methods for Oxidative N-N Coupling of an Ammonia Surrogate.

Authors:  Fei Wang; James B Gerken; Desiree M Bates; Yeon Jung Kim; Shannon S Stahl
Journal:  J Am Chem Soc       Date:  2020-06-29       Impact factor: 15.419

Review 2.  1,2,4-Triazolo[1,5-a]pyrimidines in drug design.

Authors:  Killian Oukoloff; Bobby Lucero; Karol R Francisco; Kurt R Brunden; Carlo Ballatore
Journal:  Eur J Med Chem       Date:  2019-01-14       Impact factor: 6.514

3.  A facile, practical and metal-free microwave-assisted protocol for mono- and bis-[1,2,4]triazolo[1,5-a]pyridines synthesis utilizing 1-amino-2-imino-pyridine derivatives as versatile precursors.

Authors:  Hamada Mohamed Ibrahim; Haider Behbehani; Wael Abdelgayed Ahmed Arafa
Journal:  RSC Adv       Date:  2020-04-20       Impact factor: 3.361

4.  Direct intramolecular double cross-dehydrogentive-coupling (CDC) cyclization of N-(2-pyridyl)amidines under metal-free conditions.

Authors:  Fengping Yi; Chao Fu; Qihui Sun; Huazhen Wei; Genfa Yu; Weiyin Yi
Journal:  RSC Adv       Date:  2019-12-19       Impact factor: 3.361
  4 in total

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