Literature DB >> 26112019

Non-enzymatic cyclic oxygenated metabolites of omega-3 polyunsaturated fatty acid: Bioactive drugs?

Jérôme Roy1, Jean-Yves Le Guennec2, Jean-Marie Galano3, Jérôme Thireau1, Valérie Bultel-Poncé3, Marie Demion1, Camille Oger3, Jetty Chung-Yung Lee4, Thierry Durand3.   

Abstract

Non-enzymatic oxygenated metabolites derived from polyunsaturated fatty acids (PUFA) are formed in vivo through free radical reaction under oxidative stress conditions. It has been over twenty-five years since the discovery of cyclic oxygenated metabolites derived from arachidonic acid (20:4 n-6), the isoprostanes, and since then they have become biomarkers of choice for assessing in vivo OS in humans and animals. Chemical synthesis of n-3 PUFA isoprostanoids such as F3-Isoprostanes from eicosapentaenoic acid (20:5 n-3), and F4-Neuroprostanes from docosahexaenoic acid (22:6 n-6) unravelled novel and unexpected biological properties of such omega-3 non-enzymatic cyclic metabolites as highlighted in this review.
Copyright © 2015 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved.

Entities:  

Keywords:  Arrhythmia; Isoprostanes; Neuroprostanes; Omega-3 PUFA; Oxidative stress

Mesh：

Substances：

Year:  2015        PMID： 26112019     DOI： 10.1016/j.biochi.2015.06.010

Source DB:  PubMed          Journal:  Biochimie        ISSN： 0300-9084            Impact factor:   4.079


  9 in total

1.  Adrenic acid non-enzymatic peroxidation products in biofluids of moderate preterm infants.

Authors:  Ángel Sánchez-Illana; Vidhi Shah; José David Piñeiro-Ramos; Juliann M Di Fiore; Guillermo Quintás; Thomas M Raffay; Peter M MacFarlane; Richard J Martin; Julia Kuligowski
Journal:  Free Radic Biol Med       Date:  2019-02-25       Impact factor: 7.376

2.  Intranasal Administration of Nanovectorized Docosahexaenoic Acid (DHA) Improves Cognitive Function in Two Complementary Mouse Models of Alzheimer's Disease.

Authors:  Charleine Zussy; Rijo John; Théo Urgin; Léa Otaegui; Claire Vigor; Niyazi Acar; Geoffrey Canet; Mathieu Vitalis; Françoise Morin; Emmanuel Planel; Camille Oger; Thierry Durand; Shinde L Rajshree; Laurent Givalois; Padma V Devarajan; Catherine Desrumaux
Journal:  Antioxidants (Basel)       Date:  2022-04-25

3.  Polymeric nanocapsules prevent oxidation of core-loaded molecules: evidence based on the effects of docosahexaenoic acid and neuroprostane on breast cancer cells proliferation.

Authors:  Jérôme Roy; Liliam Teixeira Oliveira; Camille Oger; Jean-Marie Galano; Valerie Bultel-Poncé; Sylvain Richard; Andrea Grabe Guimaraes; José Mário Carneiro Vilela; Margareth Spangler Andrade; Thierry Durand; Pierre Besson; Vanessa Carla Furtado Mosqueira; Jean-Yves Le Guennec
Journal:  J Exp Clin Cancer Res       Date:  2015-12-21

Review 4.  The Role of Docosahexaenoic Acid (DHA) in the Control of Obesity and Metabolic Derangements in Breast Cancer.

Authors:  Alessio Molfino; Maria Ida Amabile; Massimo Monti; Stefano Arcieri; Filippo Rossi Fanelli; Maurizio Muscaritoli
Journal:  Int J Mol Sci       Date:  2016-04-05       Impact factor: 5.923

Review 5.  ω3 Polyunsaturated Fatty Acids as Immunomodulators in Colorectal Cancer: New Potential Role in Adjuvant Therapies.

Authors:  Stefania Miccadei; Roberta Masella; Anna Maria Mileo; Sandra Gessani
Journal:  Front Immunol       Date:  2016-11-15       Impact factor: 7.561

Review 6.  Polyunsaturated Fatty Acids and Their Derivatives: Therapeutic Value for Inflammatory, Functional Gastrointestinal Disorders, and Colorectal Cancer.

Authors:  Arkadiusz Michalak; Paula Mosińska; Jakub Fichna
Journal:  Front Pharmacol       Date:  2016-12-01       Impact factor: 5.810

7.  Plasma Oxylipin Profile Discriminates Ethnicities in Subjects with Non-Alcoholic Steatohepatitis: An Exploratory Analysis.

Authors:  Tagreed A Mazi; Kamil Borkowski; Oliver Fiehn; Christopher L Bowlus; Souvik Sarkar; Karen Matsukuma; Mohamed R Ali; Dorothy A Kieffer; Yu-Jui Y Wan; Kimber L Stanhope; Peter J Havel; John W Newman; Valentina Medici
Journal:  Metabolites       Date:  2022-02-19

8.  Profiling of Omega-Polyunsaturated Fatty Acids and Their Oxidized Products in Salmon after Different Cooking Methods.

Authors:  Kin Sum Leung; Jean-Marie Galano; Thierry Durand; Jetty Chung-Yung Lee
Journal:  Antioxidants (Basel)       Date:  2018-07-24

Review 9.  Harnessing biocompatible chemistry for developing improved and novel microbial cell factories.

Authors:  Jian-Ming Liu; Christian Solem; Peter Ruhdal Jensen
Journal:  Microb Biotechnol       Date:  2019-08-06       Impact factor: 5.813
  9 in total

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