Literature DB >> 26111510

Lipid transport and human brain development.

Christer Betsholtz1.   

Abstract

How the human brain rapidly builds up its lipid content during brain growth and maintains its lipids in adulthood has remained elusive. Two new studies show that inactivating mutations in MFSD2A, known to be expressed specifically at the blood-brain barrier, lead to microcephaly, thereby offering a simple and surprising solution to an old enigma.

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Year:  2015        PMID： 26111510     DOI： 10.1038/ng.3348

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  9 in total

Review 1.  Fatty acid transport into the brain: of fatty acid fables and lipid tails.

Authors:  Ryan W Mitchell; Grant M Hatch
Journal:  Prostaglandins Leukot Essent Fatty Acids       Date:  2011-08-03       Impact factor: 4.006

2.  A partially inactivating mutation in the sodium-dependent lysophosphatidylcholine transporter MFSD2A causes a non-lethal microcephaly syndrome.

Authors:  Vafa Alakbarzade; Abdul Hameed; Debra Q Y Quek; Barry A Chioza; Emma L Baple; Amaury Cazenave-Gassiot; Long N Nguyen; Markus R Wenk; Arshia Q Ahmad; Ajith Sreekantan-Nair; Michael N Weedon; Phil Rich; Michael A Patton; Thomas T Warner; David L Silver; Andrew H Crosby
Journal:  Nat Genet       Date:  2015-05-25       Impact factor: 38.330

3.  Inactivating mutations in MFSD2A, required for omega-3 fatty acid transport in brain, cause a lethal microcephaly syndrome.

Authors:  Alicia Guemez-Gamboa; Long N Nguyen; Hongbo Yang; Maha S Zaki; Majdi Kara; Tawfeg Ben-Omran; Naiara Akizu; Rasim Ozgur Rosti; Basak Rosti; Eric Scott; Jana Schroth; Brett Copeland; Keith K Vaux; Amaury Cazenave-Gassiot; Debra Q Y Quek; Bernice H Wong; Bryan C Tan; Markus R Wenk; Murat Gunel; Stacey Gabriel; Neil C Chi; David L Silver; Joseph G Gleeson
Journal:  Nat Genet       Date:  2015-05-25       Impact factor: 38.330

4.  An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex.

Authors:  Ye Zhang; Kenian Chen; Steven A Sloan; Mariko L Bennett; Anja R Scholze; Sean O'Keeffe; Hemali P Phatnani; Paolo Guarnieri; Christine Caneda; Nadine Ruderisch; Shuyun Deng; Shane A Liddelow; Chaolin Zhang; Richard Daneman; Tom Maniatis; Ben A Barres; Jian Qian Wu
Journal:  J Neurosci       Date:  2014-09-03       Impact factor: 6.167

Review 5.  Essential polyunsaturated fatty acids and the barrier to the brain: the components of a model for transport.

Authors:  J Edmond
Journal:  J Mol Neurosci       Date:  2001 Apr-Jun       Impact factor: 3.444

Review 6.  Lysophosphatidylcholine as a preferred carrier form of docosahexaenoic acid to the brain.

Authors:  M Lagarde; N Bernoud; N Brossard; D Lemaitre-Delaunay; F Thiès; M Croset; J Lecerf
Journal:  J Mol Neurosci       Date:  2001 Apr-Jun       Impact factor: 3.444

7.  The uptake and metabolism of plasma lysophosphatidylcholine in vivo by the brain of squirrel monkeys.

Authors:  D R Illingworth; O W Portman
Journal:  Biochem J       Date:  1972-11       Impact factor: 3.857

8.  Mfsd2a is critical for the formation and function of the blood-brain barrier.

Authors:  Ayal Ben-Zvi; Baptiste Lacoste; Esther Kur; Benjamin J Andreone; Yoav Mayshar; Han Yan; Chenghua Gu
Journal:  Nature       Date:  2014-05-14       Impact factor: 49.962

9.  Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid.

Authors:  Long N Nguyen; Dongliang Ma; Guanghou Shui; Peiyan Wong; Amaury Cazenave-Gassiot; Xiaodong Zhang; Markus R Wenk; Eyleen L K Goh; David L Silver
Journal:  Nature       Date:  2014-05-14       Impact factor: 49.962
  9 in total
  11 in total

1.  Three-phase liquid extraction: a simple and fast method for lipidomic workflows.

Authors:  Gonçalo Vale; Sarah A Martin; Matthew A Mitsche; Bonne M Thompson; Kaitlyn M Eckert; Jeffrey G McDonald
Journal:  J Lipid Res       Date:  2019-01-04       Impact factor: 5.922

2.  High Dimensional Multiomics Reveals Unique Characteristics of Early Plasma Administration in Polytrauma Patients With TBI.

Authors:  Junru Wu; Hamed Moheimani; Shimena Li; Upendra K Kar; Jillian Bonaroti; Richard S Miller; Brian J Daley; Brian G Harbrecht; Jeffrey A Claridge; Danielle S Gruen; Herbert A Phelan; Francis X Guyette; Matthew D Neal; Jishnu Das; Jason L Sperry; Timothy R Billiar
Journal:  Ann Surg       Date:  2022-07-19       Impact factor: 13.787

Review 3.  Establishment and Dysfunction of the Blood-Brain Barrier.

Authors:  Zhen Zhao; Amy R Nelson; Christer Betsholtz; Berislav V Zlokovic
Journal:  Cell       Date:  2015-11-19       Impact factor: 41.582

4.  ASPM regulates symmetric stem cell division by tuning Cyclin E ubiquitination.

Authors:  Mario R Capecchi; Amir Pozner
Journal:  Nat Commun       Date:  2015-11-19       Impact factor: 14.919

Review 5.  Neuroprotective Actions of Dietary Choline.

Authors:  Jan Krzysztof Blusztajn; Barbara E Slack; Tiffany J Mellott
Journal:  Nutrients       Date:  2017-07-28       Impact factor: 5.717

Review 6.  Metabolic regulation of neurodifferentiation in the adult brain.

Authors:  Camilla Maffezzini; Javier Calvo-Garrido; Anna Wredenberg; Christoph Freyer
Journal:  Cell Mol Life Sci       Date:  2020-01-07       Impact factor: 9.261

7.  Cerebrovascular Pathology in Hypertriglyceridemic APOB-100 Transgenic Mice.

Authors:  Zsófia Hoyk; Melinda E Tóth; Nikolett Lénárt; Dóra Nagy; Brigitta Dukay; Alexandra Csefová; Ágnes Zvara; György Seprényi; András Kincses; Fruzsina R Walter; Szilvia Veszelka; Judit Vígh; Beáta Barabási; András Harazin; Ágnes Kittel; László G Puskás; Botond Penke; László Vígh; Mária A Deli; Miklós Sántha
Journal:  Front Cell Neurosci       Date:  2018-10-25       Impact factor: 5.505

8.  Embryonic periventricular endothelial cells demonstrate a unique pro-neurodevelopment and anti-inflammatory gene signature.

Authors:  Franciele Cristina Kipper; Cleide Angolano; Ravi Vissapragada; Mauricio A Contreras; Justin Moore; Manoj Bhasin; Christiane Ferran; Ajith J Thomas
Journal:  Sci Rep       Date:  2020-11-23       Impact factor: 4.379

9.  Impact of sphingosine and acetylsphingosines on the aggregation and toxicity of metal-free and metal-treated amyloid-β.

Authors:  Yelim Yi; Yuxi Lin; Jiyeon Han; Hyuck Jin Lee; Nahye Park; Geewoo Nam; Young S Park; Young-Ho Lee; Mi Hee Lim
Journal:  Chem Sci       Date:  2020-12-17       Impact factor: 9.825

10.  Lipidomics and H2(18)O labeling techniques reveal increased remodeling of DHA-containing membrane phospholipids associated with abnormal locomotor responses in α-tocopherol deficient zebrafish (danio rerio) embryos.

Authors:  Melissa Q McDougall; Jaewoo Choi; Jan F Stevens; Lisa Truong; Robert L Tanguay; Maret G Traber
Journal:  Redox Biol       Date:  2016-01-11       Impact factor: 11.799
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