Literature DB >> 26111027

DNMT3A moderates cognitive decline in subjects with mild cognitive impairment: replicated evidence from two mild cognitive impairment cohorts.

Leonidas Chouliaras1, Gunter Kenis1, Pieter Jelle Visser1,2, Philip Scheltens2, Magda Tsolaki3, Roy W Jones4, Patrick G Kehoe5, Caroline Graff6, Nicola G Girtler7, Åsa K Wallin8, Marcel Olde Rikkert9, Luiza Spiru10, Lyzel S Elias-Sonnenschein1, Inez H G B Ramakers1, Ehsan Pishva1, Jim van Os1, Harry W M Steinbusch1, Frans R J Verhey1, Daniel L A van den Hove1, Bart P F Rutten1,11.   

Abstract

Epigenetic dysregulation has been associated with cognitive decline and Alzheimer's disease. The present study investigated associations between common SNPs in genes regulating DNA methylation and age-related changes in cognitive decline in two independent prospective cohorts of patients suffering from mild cognitive impairment. An association between the rs1187120 SNP in DNMT3A and annual decline in cognitive functioning was discovered and replicated, suggesting that DNMT3A moderates cognitive decline in subjects with mild cognitive impairment.

Entities:  

Keywords:  DNA methylation; DNMT3A; MCI; SNP; aging; epigenetics; mild cognitive impairment

Mesh：

Substances：

Year:  2015        PMID： 26111027     DOI： 10.2217/epi.15.22

Source DB:  PubMed          Journal:  Epigenomics        ISSN： 1750-192X            Impact factor:   4.778


  11 in total

Review 1.  Neurobiological Highlights of Cognitive Impairment in Psychiatric Disorders.

Authors:  Anna Morozova; Yana Zorkina; Olga Abramova; Olga Pavlova; Konstantin Pavlov; Kristina Soloveva; Maria Volkova; Polina Alekseeva; Alisa Andryshchenko; Georgiy Kostyuk; Olga Gurina; Vladimir Chekhonin
Journal:  Int J Mol Sci       Date:  2022-01-22       Impact factor: 5.923

2.  Glutamine antagonist JHU083 improves psychosocial behavior and sleep deficits in EcoHIV-infected mice.

Authors:  Benjamin J Bell; Kristen R Hollinger; Pragney Deme; Shinji Sakamoto; Yuto Hasegawa; David Volsky; Atsushi Kamiya; Norman Haughey; Xiaolei Zhu; Barbara S Slusher
Journal:  Brain Behav Immun Health       Date:  2022-06-09

3.  The synergistic risk effect of apolipoprotein ε4 and DNA (cytosine-5-)-methyltransferase 3 beta (DNMT3B) haplotype for Alzheimer's disease.

Authors:  Cíntia Monique Boschmann Ens de Bem; Julio Carlos Pezzi; Ericksen Mielle Borba; Marcia Lorena Fagundes Chaves; Fabiana Michelsen de Andrade; Marilu Fiegenbaum; Analuiza Camozzato
Journal:  Mol Biol Rep       Date:  2016-05-17       Impact factor: 2.316

Review 4.  Epigenetics of Aging and Alzheimer's Disease: Implications for Pharmacogenomics and Drug Response.

Authors:  Ramón Cacabelos; Clara Torrellas
Journal:  Int J Mol Sci       Date:  2015-12-21       Impact factor: 5.923

5.  DNA Hypomethylation in Blood Links B3GALT4 and ZADH2 to Alzheimer's Disease.

Authors:  Andy Madrid; Kirk J Hogan; Ligia A Papale; Lindsay R Clark; Sanjay Asthana; Sterling C Johnson; Reid S Alisch
Journal:  J Alzheimers Dis       Date:  2018       Impact factor: 4.472

6.  Association study between the DNMT3A -448A>G polymorphism and risk of Alzheimer's disease in Caucasians of Italian origin.

Authors:  Pierpaola Tannorella; Andrea Stoccoro; Gloria Tognoni; Ubaldo Bonuccelli; Lucia Migliore; Fabio Coppedè
Journal:  Am J Neurodegener Dis       Date:  2016-03-01

7.  Epigenetic mechanisms underlying cognitive impairment and Alzheimer disease hallmarks in 5XFAD mice.

Authors:  Christian Griñán-Ferré; Sara Sarroca; Aleksandra Ivanova; Dolors Puigoriol-Illamola; Fernando Aguado; Antoni Camins; Coral Sanfeliu; Mercè Pallàs
Journal:  Aging (Albany NY)       Date:  2016-04       Impact factor: 5.682

Review 8.  Genetic Biomarkers on Age-Related Cognitive Decline.

Authors:  Chieh-Hsin Lin; Eugene Lin; Hsien-Yuan Lane
Journal:  Front Psychiatry       Date:  2017-11-21       Impact factor: 4.157

Review 9.  Neuronal DNA Methyltransferases: Epigenetic Mediators between Synaptic Activity and Gene Expression?

Authors:  Gonca Bayraktar; Michael R Kreutz
Journal:  Neuroscientist       Date:  2017-05-17       Impact factor: 7.519

Review 10.  DNA Methyltransferases, DNA Methylation, and Age-Associated Cognitive Function.

Authors:  Di Cui; Xiangru Xu
Journal:  Int J Mol Sci       Date:  2018-04-28       Impact factor: 5.923
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