Literature DB >> 26110966

Enhanced Solvation of Peptides Attached to "Solid-Phase" Resins: Straightforward Syntheses of the Elastin Sequence Pro-Gly-Val-Gly-Val-Pro-Gly-Val-Gly-Val.

Bobo Dang1, Balamurugan Dhayalan1, Stephen B H Kent1.   

Abstract

The solubility-enhancing power of covalent attachment to solvent-swollen cross-linked resin supports was illustrated by syntheses of the highly aggregating elastin-derived 10-residue peptide sequence Pro-Gly-Val-Gly-Val-Pro-Gly-Val-Gly-Val using standard protocols for both Boc and Fmoc chemistry SPPS.

Entities:  

Year:  2015        PMID： 26110966     DOI： 10.1021/acs.orglett.5b01632

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  4 in total

1.  A fully automated flow-based approach for accelerated peptide synthesis.

Authors:  Alexander J Mijalis; Dale A Thomas; Mark D Simon; Andrea Adamo; Ryan Beaumont; Klavs F Jensen; Bradley L Pentelute
Journal:  Nat Chem Biol       Date:  2017-02-28       Impact factor: 15.040

2.  A backbone amide protecting group for overcoming difficult sequences and suppressing aspartimide formation.

Authors:  Abu-Baker M Abdel-Aal; George Papageorgiou; Richard Raz; Martin Quibell; Fabienne Burlina; John Offer
Journal:  J Pept Sci       Date:  2016-04-18       Impact factor: 1.905

3.  Expedient on-resin modification of a peptide C-terminus through a benzotriazole linker.

Authors:  Anand Selvaraj; Hui-Ting Chen; Adela Ya-Ting Huang; Chai-Lin Kao
Journal:  Chem Sci       Date:  2017-10-30       Impact factor: 9.825

4.  HF-Free Boc Synthesis of Peptide Thioesters for Ligation and Cyclization.

Authors:  Richard Raz; Fabienne Burlina; Mohamed Ismail; Julian Downward; Jiejin Li; Stephen J Smerdon; Martin Quibell; Peter D White; John Offer
Journal:  Angew Chem Int Ed Engl       Date:  2016-10-10       Impact factor: 15.336
  4 in total

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