PURPOSE: To quantify the physical activity in daily life (PADL), muscle strength, and exercise capacity in the short and medium term in survivors of severe sepsis and septic shock. METHODS: Prospective cohort study with a follow-up from hospital admission to 3 months after hospital discharge. Seventy-two patients admitted to the ICU for severe sepsis or septic shock and a control group of healthy sedentary subjects (n = 50) were enrolled. All patients had their PADL quantified by an accelerometer during their hospital stay and 3 months after. Exercise capacity and handgrip and quadriceps muscle strength were also evaluated. RESULTS: During hospitalization, patients spent the majority of their time inactive in a lying or sitting position (90 ± 34% of daily time). Physical inactivity was partially reduced 3 months after (58 ± 20% of daily time). However, the time patients spent walking was only 63% of the time reported for healthy subjects. Patients also showed lower movement intensity when compared with controls (2.1 ± 0.3 vs 2.5 ± 0.4 m/s(2)). At hospital discharge, muscle strength and exercise capacity were approximately 54% of the predicted value, and these parameters showed significant increase in patients 3 months after (70% of predicted value). Multivariable analysis demonstrated that the use of systemic corticosteroids and hospitalization time negatively influenced quadriceps strength and exercise capacity at the time of hospital discharge. CONCLUSION: Our results suggest that survivors of sepsis admitted to the ICU have a substantial reduction in physical activity, exercise capacity, and muscle strength compared to healthy subjects that persist even 3 months after hospital discharge.
PURPOSE: To quantify the physical activity in daily life (PADL), muscle strength, and exercise capacity in the short and medium term in survivors of severe sepsis and septic shock. METHODS: Prospective cohort study with a follow-up from hospital admission to 3 months after hospital discharge. Seventy-two patients admitted to the ICU for severe sepsis or septic shock and a control group of healthy sedentary subjects (n = 50) were enrolled. All patients had their PADL quantified by an accelerometer during their hospital stay and 3 months after. Exercise capacity and handgrip and quadriceps muscle strength were also evaluated. RESULTS: During hospitalization, patients spent the majority of their time inactive in a lying or sitting position (90 ± 34% of daily time). Physical inactivity was partially reduced 3 months after (58 ± 20% of daily time). However, the time patients spent walking was only 63% of the time reported for healthy subjects. Patients also showed lower movement intensity when compared with controls (2.1 ± 0.3 vs 2.5 ± 0.4 m/s(2)). At hospital discharge, muscle strength and exercise capacity were approximately 54% of the predicted value, and these parameters showed significant increase in patients 3 months after (70% of predicted value). Multivariable analysis demonstrated that the use of systemic corticosteroids and hospitalization time negatively influenced quadriceps strength and exercise capacity at the time of hospital discharge. CONCLUSION: Our results suggest that survivors of sepsis admitted to the ICU have a substantial reduction in physical activity, exercise capacity, and muscle strength compared to healthy subjects that persist even 3 months after hospital discharge.
Authors: Fabio Pitta; Thierry Troosters; Martijn A Spruit; Vanessa S Probst; Marc Decramer; Rik Gosselink Journal: Am J Respir Crit Care Med Date: 2005-01-21 Impact factor: 21.405
Authors: Margaret S Herridge; Angela M Cheung; Catherine M Tansey; Andrea Matte-Martyn; Natalia Diaz-Granados; Fatma Al-Saidi; Andrew B Cooper; Cameron B Guest; C David Mazer; Sangeeta Mehta; Thomas E Stewart; Aiala Barr; Deborah Cook; Arthur S Slutsky Journal: N Engl J Med Date: 2003-02-20 Impact factor: 91.245
Authors: Fábio Pitta; Marie-Kathrin Breyer; Nídia A Hernandes; Denílson Teixeira; Thaís J P Sant'Anna; Andréa D Fontana; Vanessa S Probst; Antonio F Brunetto; Martijn A Spruit; Emiel F M Wouters; Otto C Burghuber; Sylvia Hartl Journal: Respir Med Date: 2008-11-09 Impact factor: 3.415
Authors: Juan C Mira; Lori F Gentile; Brittany J Mathias; Philip A Efron; Scott C Brakenridge; Alicia M Mohr; Frederick A Moore; Lyle L Moldawer Journal: Crit Care Med Date: 2017-02 Impact factor: 7.598
Authors: P Mason McClatchey; Michal Schafer; Kendall S Hunter; Jane E B Reusch Journal: Am J Physiol Heart Circ Physiol Date: 2016-05-06 Impact factor: 4.733
Authors: Stephanie Parks Taylor; Shih-Hsiung Chou; Marielys Figueroa Sierra; Thomas P Shuman; Andrew D McWilliams; Brice T Taylor; Mark Russo; Susan L Evans; Whitney Rossman; Stephanie Murphy; Kyle Cunningham; Marc A Kowalkowski Journal: Ann Am Thorac Soc Date: 2020-01