Adnan N Kiani1, Laurence S Magder2, Wendy S Post1, Moyses Szklo3, Joan M Bathon1, Pam J Schreiner4, Daniel O'Leary5, Michelle Petri6. 1. Department of Medicine, Division of Rheumatology, Johns Hopkins University. 2. Department of Epidemiology and Preventive Medicine, University of Maryland. 3. Department of Epidemiology, School of Medicine and Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD. 4. Department of Epidemiology, Division of Epidemiology & Community Health, University of Minnesota, Minneapolis, MN and. 5. Department of Medicine, Tufts University School of Medicine, Boston, MA, USA. 6. Department of Medicine, Division of Rheumatology, Johns Hopkins University, mpetri@jhmi.edu.
Abstract
OBJECTIVE: Accelerated atherosclerosis is a major cause of morbidity and death in SLE. The purpose of this study was to determine whether the prevalence and extent of coronary artery calcium (CAC) is higher in female SLE patients compared with a non-SLE sample from the Multi-Ethnic Study of Atherosclerosis (MESA). METHODS: CAC was measured in 80 female SLE patients and 241 female MESA controls from the Baltimore Field Centre, ages 45-64 years, without evidence of clinical cardiovascular disease. Binary regression was used to estimate the ratio of CAC prevalence in SLE vs MESA controls, controlling for demographic and cardiovascular risk factors. To compare the groups with respect to the quantity of CAC among those with non-zero Agatston scores, we used linear models in which the outcome was a log-transformed Agatston score. RESULTS: The prevalence of CAC was substantially higher in SLE. The differences were most pronounced and statistically significant in those aged 45-54 years (58% vs 20%, P < 0.0001), but were still observed among those aged 55-65 years (57% vs 36%, P = 0.069). After controlling for age, ethnicity, education, income, diabetes mellitus, hypertension, hyperlipidaemia, high-density lipoprotein levels, smoking, education and BMI, SLE patients still had a significantly higher prevalence of CAC than controls. Among those with CAC, the mean log Agatston score did not differ significantly between SLE and MESA participants. CONCLUSION: Women with SLE have a higher prevalence of CAC than comparable women without SLE, even after adjusting for traditional cardiovascular risk factors, especially among those aged 45-54 years. Published by Oxford University Press 2015. This work is written by US Government employees and is in the public domain in the US.
OBJECTIVE: Accelerated atherosclerosis is a major cause of morbidity and death in SLE. The purpose of this study was to determine whether the prevalence and extent of coronary artery calcium (CAC) is higher in female SLEpatients compared with a non-SLE sample from the Multi-Ethnic Study of Atherosclerosis (MESA). METHODS: CAC was measured in 80 female SLEpatients and 241 female MESA controls from the Baltimore Field Centre, ages 45-64 years, without evidence of clinical cardiovascular disease. Binary regression was used to estimate the ratio of CAC prevalence in SLE vs MESA controls, controlling for demographic and cardiovascular risk factors. To compare the groups with respect to the quantity of CAC among those with non-zero Agatston scores, we used linear models in which the outcome was a log-transformed Agatston score. RESULTS: The prevalence of CAC was substantially higher in SLE. The differences were most pronounced and statistically significant in those aged 45-54 years (58% vs 20%, P < 0.0001), but were still observed among those aged 55-65 years (57% vs 36%, P = 0.069). After controlling for age, ethnicity, education, income, diabetes mellitus, hypertension, hyperlipidaemia, high-density lipoprotein levels, smoking, education and BMI, SLEpatients still had a significantly higher prevalence of CAC than controls. Among those with CAC, the mean log Agatston score did not differ significantly between SLE and MESA participants. CONCLUSION:Women with SLE have a higher prevalence of CAC than comparable women without SLE, even after adjusting for traditional cardiovascular risk factors, especially among those aged 45-54 years. Published by Oxford University Press 2015. This work is written by US Government employees and is in the public domain in the US.
Authors: Yu Asanuma; Annette Oeser; Ayumi K Shintani; Elizabeth Turner; Nancy Olsen; Sergio Fazio; MacRae F Linton; Paolo Raggi; C Michael Stein Journal: N Engl J Med Date: 2003-12-18 Impact factor: 91.245
Authors: Joseph Shemesh; Nira Morag-Koren; Uri Goldbourt; Ehud Grossman; Alexander Tenenbaum; Enrique Z Fisman; Sara Apter; Yacov Itzchak; Michael Motro Journal: J Hypertens Date: 2004-03 Impact factor: 4.844
Authors: George T Kondos; Julie Anne Hoff; Alexander Sevrukov; Martha L Daviglus; Daniel B Garside; Stephen S Devries; Eva V Chomka; Kiang Liu Journal: Circulation Date: 2003-05-12 Impact factor: 29.690
Authors: Diane E Bild; David A Bluemke; Gregory L Burke; Robert Detrano; Ana V Diez Roux; Aaron R Folsom; Philip Greenland; David R Jacob; Richard Kronmal; Kiang Liu; Jennifer Clark Nelson; Daniel O'Leary; Mohammed F Saad; Steven Shea; Moyses Szklo; Russell P Tracy Journal: Am J Epidemiol Date: 2002-11-01 Impact factor: 4.897
Authors: I G Poornima; K Shields; L H Kuller; S M Manzi; R Ramsey-Goldman; C Richardson; E Rhew; D D Dunlop; J Song; D Edmundowicz; G T Kondos; J J Carr; C B Langman; H Price; A H Chung; L B Santelices; R H Mackey Journal: Lupus Date: 2018-01-01 Impact factor: 2.911
Authors: Benjamin D Long; Jadranka Stojanovska; Richard K J Brown; Anil K Attili; Eizabeth A Jackson; Vladimir Ognenovski Journal: Acad Radiol Date: 2017-08-26 Impact factor: 3.173
Authors: Johanna T Gustafsson; Marie Herlitz Lindberg; Iva Gunnarsson; Susanne Pettersson; Kerstin Elvin; John Öhrvik; Anders Larsson; Kerstin Jensen-Urstad; Elisabet Svenungsson Journal: PLoS One Date: 2017-04-17 Impact factor: 3.240