Dragan A Stojanov1,2, Aleksandra Aracki-Trenkic3, Slobodan Vojinovic4,5, Daniela Benedeto-Stojanov6, Srdjan Ljubisavljevic7,8. 1. Faculty of Medicine, University of Nis, Nis, Serbia, Bul. Dr. Z. Djindjica 82. drstojanov@gmail.com. 2. Center for Radiology, Clinical Center Nis, Nis, Serbia, Bul. Dr. Z. Djindjica 48. drstojanov@gmail.com. 3. Center for Radiology, Clinical Center Nis, Nis, Serbia, Bul. Dr. Z. Djindjica 48. aaracki@gmail.com. 4. Faculty of Medicine, University of Nis, Nis, Serbia, Bul. Dr. Z. Djindjica 82. boban2@eunet.rs. 5. Clinic for Neurology, Clinical Center Nis, Nis, Serbia, Bul. Dr. Z. Djindjica 48. boban2@eunet.rs. 6. Faculty of Medicine, University of Nis, Nis, Serbia, Bul. Dr. Z. Djindjica 82. stojanovd@ptt.rs. 7. Faculty of Medicine, University of Nis, Nis, Serbia, Bul. Dr. Z. Djindjica 82. srljub@gmail.com. 8. Clinic for Neurology, Clinical Center Nis, Nis, Serbia, Bul. Dr. Z. Djindjica 48. srljub@gmail.com.
Abstract
OBJECTIVE: To evaluate correlation between cumulative dose of gadobutrol and signal intensity (SI) within dentate nucleus and globus pallidus on unenhanced T1-weighted images in patients with relapsing-remitting multiple sclerosis (RRMS). METHODS: Dentate nucleus-to-pons and globus pallidus-to-thalamus SI ratios, and renal and liver functions, were evaluated after multiple intravenous administrations of 0.1 mmol/kg gadobutrol at 27, 96-98, and 168 weeks. We compared SI ratios based on the number of administrations, total amount of gadobutrol administered, and time between injections. RESULTS: Globus pallidus-to-thalamus (p = 0.025) and dentate nucleus-to-pons (p < 0.001) SI ratios increased after multiple gadobutrol administrations, correlated with the number of administrations (ρ = 0.263, p = 0.046, respectively) and depended on the length of administration (p = 0.017, p = 0.037, respectively). Patients receiving gadobutrol at 27 weeks showed the greatest increase in both SI ratios (p = 0.006; p = 0.014, respectively, versus 96-98 weeks). GGT increased at the end of the study (p = 0.004). CONCLUSION: In patients with RRMS, SI within the dentate nucleus and globus pallidus increased on unenhanced T1-weighted images after multiple gadobutrol injections. Administration of the same total amount of gadobutrol over a shorter period caused greater SI increase. KEY POINTS: Gadolinium deposition may occur within the human brain after multiple gadolinium contrast administrations. Increasing T1W signal intensity occurs within the dentate nucleus and globus pallidus. Increasing signal intensity may be a consequence of multiple administrations of gadobutrol. Administration of gadobutrol over a shorter period causes greater signal intensity increase.
OBJECTIVE: To evaluate correlation between cumulative dose of gadobutrol and signal intensity (SI) within dentate nucleus and globus pallidus on unenhanced T1-weighted images in patients with relapsing-remitting multiple sclerosis (RRMS). METHODS: Dentate nucleus-to-pons and globus pallidus-to-thalamus SI ratios, and renal and liver functions, were evaluated after multiple intravenous administrations of 0.1 mmol/kg gadobutrol at 27, 96-98, and 168 weeks. We compared SI ratios based on the number of administrations, total amount of gadobutrol administered, and time between injections. RESULTS: Globus pallidus-to-thalamus (p = 0.025) and dentate nucleus-to-pons (p < 0.001) SI ratios increased after multiple gadobutrol administrations, correlated with the number of administrations (ρ = 0.263, p = 0.046, respectively) and depended on the length of administration (p = 0.017, p = 0.037, respectively). Patients receiving gadobutrol at 27 weeks showed the greatest increase in both SI ratios (p = 0.006; p = 0.014, respectively, versus 96-98 weeks). GGT increased at the end of the study (p = 0.004). CONCLUSION: In patients with RRMS, SI within the dentate nucleus and globus pallidus increased on unenhanced T1-weighted images after multiple gadobutrol injections. Administration of the same total amount of gadobutrol over a shorter period caused greater SI increase. KEY POINTS: Gadolinium deposition may occur within the human brain after multiple gadolinium contrast administrations. Increasing T1W signal intensity occurs within the dentate nucleus and globus pallidus. Increasing signal intensity may be a consequence of multiple administrations of gadobutrol. Administration of gadobutrol over a shorter period causes greater signal intensity increase.
Authors: Martin A Sieber; Philipp Lengsfeld; Thomas Frenzel; Sven Golfier; Heribert Schmitt-Willich; Fred Siegmund; Jakob Walter; Hanns-Joachim Weinmann; Hubertus Pietsch Journal: Eur Radiol Date: 2008-06-11 Impact factor: 5.315
Authors: T Dobrocky; A Winklehner; P S Breiding; L Grunder; G Peschi; L Häni; P J Mosimann; M Branca; J Kaesmacher; P Mordasini; A Raabe; C T Ulrich; J Beck; J Gralla; E I Piechowiak Journal: AJNR Am J Neuroradiol Date: 2020-06-18 Impact factor: 3.825