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Literature DB >> 26104458

V(D)J Recombination: Mechanism, Errors, and Fidelity.

Abstract

V(D)J recombination, the mechanism responsible for generating antigen receptor diversity, has the potential to generate aberrant DNA rearrangements in developing lymphocytes. Indeed, the recombinase has been implicated in several different kinds of errors leading to oncogenic transformation. Here we review the basic aspects of V(D)J recombination, mechanisms underlying aberrant DNA rearrangements, and the types of aberrant events uncovered in recent genomewide analyses of lymphoid neoplasms.

Entities: Chemical Disease Gene Mutation Species

Mesh：

Substances：

Year: 2014 PMID： 26104458 PMCID： PMC5089068 DOI： 10.1128/microbiolspec.MDNA3-0041-2014

Source DB: PubMed Journal: Microbiol Spectr ISSN： 2165-0497

86 in total

1. Separation-of-function mutants reveal critical roles for RAG2 in both the cleavage and joining steps of V(D)J recombination.

Authors: J X Qiu; S B Kale; H Yarnell Schultz; D B Roth
Journal: Mol Cell Date: 2001-01 Impact factor: 17.970

2. RAG proteins shepherd double-strand breaks to a specific pathway, suppressing error-prone repair, but RAG nicking initiates homologous recombination.

Authors: Gregory S Lee; Matthew B Neiditch; Sandra S Salus; David B Roth
Journal: Cell Date: 2004-04-16 Impact factor: 41.582

3. An activating intragenic deletion in NOTCH1 in human T-ALL.

Authors: J Erika Haydu; Kim De Keersmaecker; Mary Kaye Duff; Elisabeth Paietta; Janis Racevskis; Peter H Wiernik; Jacob M Rowe; Adolfo Ferrando
Journal: Blood Date: 2012-04-17 Impact factor: 22.113

4. Genomic instability due to V(D)J recombination-associated transposition.

Authors: Yeturu V R Reddy; Eric J Perkins; Dale A Ramsden
Journal: Genes Dev Date: 2006-06-15 Impact factor: 11.361

Review 5. V(D)J recombination: mechanisms of initiation.

Authors: David G Schatz; Patrick C Swanson
Journal: Annu Rev Genet Date: 2011-08-19 Impact factor: 16.830

6. Distinct DNA sequence and structure requirements for the two steps of V(D)J recombination signal cleavage.

Authors: D A Ramsden; J F McBlane; D C van Gent; M Gellert
Journal: EMBO J Date: 1996-06-17 Impact factor: 11.598

7. RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia.

Authors: Elli Papaemmanuil; Inmaculada Rapado; Yilong Li; Nicola E Potter; David C Wedge; Jose Tubio; Ludmil B Alexandrov; Peter Van Loo; Susanna L Cooke; John Marshall; Inigo Martincorena; Jonathan Hinton; Gunes Gundem; Frederik W van Delft; Serena Nik-Zainal; David R Jones; Manasa Ramakrishna; Ian Titley; Lucy Stebbings; Catherine Leroy; Andrew Menzies; John Gamble; Ben Robinson; Laura Mudie; Keiran Raine; Sarah O'Meara; Jon W Teague; Adam P Butler; Giovanni Cazzaniga; Andrea Biondi; Jan Zuna; Helena Kempski; Markus Muschen; Anthony M Ford; Michael R Stratton; Mel Greaves; Peter J Campbell
Journal: Nat Genet Date: 2014-01-12 Impact factor: 38.330

8. Extrachromosomal DNA substrates in pre-B cells undergo inversion or deletion at immunoglobulin V-(D)-J joining signals.

Authors: J E Hesse; M R Lieber; M Gellert; K Mizuuchi
Journal: Cell Date: 1987-06-19 Impact factor: 41.582

9. Similarities between initiation of V(D)J recombination and retroviral integration.

Authors: D C van Gent; K Mizuuchi; M Gellert
Journal: Science Date: 1996-03-15 Impact factor: 47.728

Review 10. The mechanism of V(D)J joining: lessons from molecular, immunological, and comparative analyses.

Authors: S M Lewis
Journal: Adv Immunol Date: 1994 Impact factor: 3.543

35 in total

Review 1. The Ku complex: recent advances and emerging roles outside of non-homologous end-joining.

Authors: Sanna Abbasi; Gursimran Parmar; Rachel D Kelly; Nileeka Balasuriya; Caroline Schild-Poulter
Journal: Cell Mol Life Sci Date: 2021-04-15 Impact factor: 9.261

2. Restoration of ATM Expression in DNA-PKcs-Deficient Cells Inhibits Signal End Joining.

Authors: Jessica A Neal; Yao Xu; Masumi Abe; Eric Hendrickson; Katheryn Meek
Journal: J Immunol Date: 2016-02-26 Impact factor: 5.422

Review 3. Brain cell somatic gene recombination and its phylogenetic foundations.

Authors: Gwendolyn Kaeser; Jerold Chun
Journal: J Biol Chem Date: 2020-07-22 Impact factor: 5.157

4. Structural and Mechanistic Implications of Rearrangement Frequencies within Human TCRBV Genes.

Authors: Maryam B Yassai; Wendy Demos; Jack Gorski
Journal: J Immunol Date: 2017-06-28 Impact factor: 5.422

5. Autophosphorylation transforms DNA-PK from protecting to processing DNA ends.

Authors: Lan Liu; Xuemin Chen; Jun Li; Huaibin Wang; Christopher J Buehl; Noah J Goff; Katheryn Meek; Wei Yang; Martin Gellert
Journal: Mol Cell Date: 2021-12-21 Impact factor: 17.970

Review 6. Interactions of high mobility group box protein 1 (HMGB1) with nucleic acids: Implications in DNA repair and immune responses.

Authors: Pooja Mandke; Karen M Vasquez
Journal: DNA Repair (Amst) Date: 2019-09-16

Review 7. Riches in RAGs: Revealing the V(D)J Recombinase through High-Resolution Structures.

Authors: Karla K Rodgers
Journal: Trends Biochem Sci Date: 2016-11-05 Impact factor: 13.807

Review 8. Genetics of Cutaneous T Cell Lymphoma: From Bench to Bedside.

Authors: William E Damsky; Jaehyuk Choi
Journal: Curr Treat Options Oncol Date: 2016-07

9. Mapping replication dynamics in Trypanosoma brucei reveals a link with telomere transcription and antigenic variation.

Authors: Rebecca Devlin; Catarina A Marques; Daniel Paape; Marko Prorocic; Andrea C Zurita-Leal; Samantha J Campbell; Craig Lapsley; Nicholas Dickens; Richard McCulloch
Journal: Elife Date: 2016-05-26 Impact factor: 8.140

10. Staring at the Naked Goddess: Unraveling the Structure and Reactivity of Artemis Endonuclease Interacting with a DNA Double Strand.

Authors: Cécilia Hognon; Antonio Monari
Journal: Molecules Date: 2021-06-29 Impact factor: 4.411