K Y Wang1, O Idowu2, C B Thompson3, G Orman2, C Myers4, L H Riley5, J A Carrino6, A Flammang7, W Gilson8, C L Sadowsky9, I Izbudak10. 1. Johns Hopkins University School of Medicine, Baltimore, MD, USA. 2. Division of Neuroradiology, Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 600 North Wolfe Street, 21287, Phipps B-126-B, Baltimore, MD, USA. 3. Johns Hopkins Biostatistics Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. 4. Diagnostic Imaging at Anne Arundel Medical Center, Annapolis, MD, USA. 5. Department of Orthopedic Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA. 6. Department of Radiology and Imaging, Hospital for Special Surgery, New York, NY, USA. 7. Siemens Corporate Research, Center for Applied Medical Imaging, Orange, CA, USA. 8. Siemens Corporate Research, Imaging and Visualization, Baltimore, MD, USA. 9. Kennedy Krieger Institute, International Center for Spinal Cord Injury, Baltimore, MD, USA. 10. Division of Neuroradiology, Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 600 North Wolfe Street, 21287, Phipps B-126-B, Baltimore, MD, USA. iizbuda1@jhmi.edu.
Abstract
PURPOSE: Diffusion tensor imaging (DTI) metrics of the cervical spinal cord in patients with cervical spondylotic myelopathy (CSM) were compared to those measured in healthy volunteers, using tract-specific region of interests (ROIs) across all cervical intervertebral disc levels. METHODS: Magnetic resonance (MR) imaging of the cervical spinal cord was performed in four patients with CSM and in five healthy volunteers on a 3-T MR scanner. Region-specific fractional anisotropy (FA) and mean diffusivity (MD) were calculated on axial imaging with ROI placement in the anterior, lateral, and posterior regions of the spinal cord. FA and MD were also calculated on sagittal acquisitions. Nonparametric statistical tests were used to compare controls and patients before and after surgery. RESULTS: FA values were significantly lower (p = 0.050) and MD values were significantly higher (p = 0.014) in CSM patients measured at level of maximal compression before surgery than in healthy controls in lateral and posterior ROIs, respectively. In posterior ROIs, MD values were significantly higher in patients before surgery compared to controls at all levels except C7-T1. CONCLUSION: Patients with CSM may demonstrate region-specific changes in DTI metrics when compared to healthy controls. Changes in DTI metrics may also occur at levels remote from site of compression.
PURPOSE: Diffusion tensor imaging (DTI) metrics of the cervical spinal cord in patients with cervical spondylotic myelopathy (CSM) were compared to those measured in healthy volunteers, using tract-specific region of interests (ROIs) across all cervical intervertebral disc levels. METHODS: Magnetic resonance (MR) imaging of the cervical spinal cord was performed in four patients with CSM and in five healthy volunteers on a 3-T MR scanner. Region-specific fractional anisotropy (FA) and mean diffusivity (MD) were calculated on axial imaging with ROI placement in the anterior, lateral, and posterior regions of the spinal cord. FA and MD were also calculated on sagittal acquisitions. Nonparametric statistical tests were used to compare controls and patients before and after surgery. RESULTS: FA values were significantly lower (p = 0.050) and MD values were significantly higher (p = 0.014) in CSM patients measured at level of maximal compression before surgery than in healthy controls in lateral and posterior ROIs, respectively. In posterior ROIs, MD values were significantly higher in patients before surgery compared to controls at all levels except C7-T1. CONCLUSION:Patients with CSM may demonstrate region-specific changes in DTI metrics when compared to healthy controls. Changes in DTI metrics may also occur at levels remote from site of compression.
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