Literature DB >> 26103056

Electrocatalysis by subcellular liver fractions bound to carbon nanostructures for stereoselective green drug metabolite synthesis.

Rajasekhara Nerimetla1, Sadagopan Krishnan.   

Abstract

A novel, reusable, cofactor-free, and mediator-free human liver microsomal bioreactor constructed on carbon nanostructure electrodes for stereoselective green syntheses of drug metabolites and specialty chemicals is reported here for the first time. Drug metabolites are useful for examining pharmaceutical and pharmacological properties of new drugs under development.

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Year:  2015        PMID： 26103056      PMCID： PMC4496290          DOI： 10.1039/c5cc03364k

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  21 in total

1.  Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes.

Authors:  H Yamazaki; T Shimada
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Review 2.  New electrodes for old: from carbon nanotubes to edge plane pyrolytic graphite.

Authors:  Craig E Banks; Richard G Compton
Journal:  Analyst       Date:  2006-01       Impact factor: 4.616

3.  Cytochromes P450 as useful biocatalysts: addressing the limitations.

Authors:  Elaine O'Reilly; Valentin Köhler; Sabine L Flitsch; Nicholas J Turner
Journal:  Chem Commun (Camb)       Date:  2011-01-24       Impact factor: 6.222

4.  Preclinical in vitro screening assays for drug-like properties.

Authors:  Albert P Li
Journal:  Drug Discov Today Technol       Date:  2005

5.  A simple construction of electrochemical liver microsomal bioreactor for rapid drug metabolism and inhibition assays.

Authors:  Charuksha Walgama; Rajasekhara Nerimetla; Nicholas F Materer; Deniz Schildkraut; James F Elman; Sadagopan Krishnan
Journal:  Anal Chem       Date:  2015-04-22       Impact factor: 6.986

Review 6.  Pharmacogenetics, pharmacogenomics, and individualized medicine.

Authors:  Qiang Ma; Anthony Y H Lu
Journal:  Pharmacol Rev       Date:  2011-03-24       Impact factor: 25.468

Review 7.  Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation.

Authors:  Ulrich M Zanger; Matthias Schwab
Journal:  Pharmacol Ther       Date:  2013-01-16       Impact factor: 12.310

Review 8.  Mechanisms of cytochrome P450 substrate oxidation: MiniReview.

Authors:  F Peter Guengerich
Journal:  J Biochem Mol Toxicol       Date:  2007       Impact factor: 3.642

Review 9.  Unusual cytochrome p450 enzymes and reactions.

Authors:  F Peter Guengerich; Andrew W Munro
Journal:  J Biol Chem       Date:  2013-04-30       Impact factor: 5.157

10.  Drug-induced oxidative stress and toxicity.

Authors:  Damian G Deavall; Elizabeth A Martin; Judith M Horner; Ruth Roberts
Journal:  J Toxicol       Date:  2012-08-05
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  2 in total

Review 1.  Engineering cytochrome P450 enzyme systems for biomedical and biotechnological applications.

Authors:  Zhong Li; Yuanyuan Jiang; F Peter Guengerich; Li Ma; Shengying Li; Wei Zhang
Journal:  J Biol Chem       Date:  2019-12-06       Impact factor: 5.157

2.  Stability, Scalability, and Reusability of a Volume Efficient Biocatalytic System Constructed on Magnetic Nanoparticles.

Authors:  Gayan Premaratne; Rajasekhara Nerimetla; Ryan Matlock; Loren Sunday; Rangika S Hikkaduwa Koralege; Joshua D Ramsey; Sadagopan Krishnan
Journal:  Catal Sci Technol       Date:  2015-11-19       Impact factor: 6.119
  2 in total

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