Preclinical in vitro screening assays for drug-like properties.

Besides pharmacological effects, ADMET drug properties, namely, absorption, disposition, metabolism, elimination and toxicity, are important drug properties critical for clinical success. In vitro human-based experimental system used in combination with in vivo animal systems, using animal species relevant to humans, represent the best approach to assess these important drug-like properties before clinical trials. Selection of drug candidates with the best ADMET properties should enhance the probability of clinical success.: