Pejman Ghanouni1, Kim Butts Pauly2, W Jeff Elias3, Jaimie Henderson4, Jason Sheehan3, Stephen Monteith5, Max Wintermark6. 1. 1 Division of Body MRI, Department of Radiology, Stanford University, Stanford, CA. 2. 2 Departments of Radiology and Electrical Engineering and Bioengineering, Stanford University, Stanford, CA. 3. 3 Department of Neurosurgery, University of Virginia, Charlottesville, VA. 4. 4 Department of Neurosurgery and Neurology and Neurological Sciences, Stanford University, Stanford, CA. 5. 5 Department of Neurosurgery, Swedish Medical Center, Seattle, WA. 6. 6 Present address: Division of Neuroradiology, Department of Radiology, Stanford University, 300 Pasteur Dr, Rm S047, Stanford, CA 94305-5105.
Abstract
OBJECTIVE: This article reviews the physical principles of MRI-guided focused ultra-sound and discusses current and potential applications of this exciting technology. CONCLUSION: MRI-guided focused ultrasound is a new minimally invasive method of targeted tissue thermal ablation that may be of use to treat central neuropathic pain, essential tremor, Parkinson tremor, and brain tumors. The system has also been used to temporarily disrupt the blood-brain barrier to allow targeted drug delivery to brain tumors.
OBJECTIVE: This article reviews the physical principles of MRI-guided focused ultra-sound and discusses current and potential applications of this exciting technology. CONCLUSION: MRI-guided focused ultrasound is a new minimally invasive method of targeted tissue thermal ablation that may be of use to treat central neuropathic pain, essential tremor, Parkinson tremor, and brain tumors. The system has also been used to temporarily disrupt the blood-brain barrier to allow targeted drug delivery to brain tumors.
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