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Literature DB >> 26101549

Synthesis and cytotoxicity studies of 1-propenyl-1,3-dihydro-benzimidazol-2-one.

Biswadip Banerji¹, Sumit Kumar Pramanik¹.

Abstract

A heterocyclic compound 1-propenyl-1,3-dihydro-benzimidazol-2-one was synthesized by a palladium-catalyzed rearrangement reaction. Anticancer activities were confirmed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay against Neura 2a (neuroblastoma cell), HEK 293 (kidney cancer) and MCF-7 (breast cancer) cell lines at low micromolar range. Furthermore, clear images from phase-contrast and fluorescence microscopes and confocal images unambiguously confirm the cancer cell death. The single X-ray crystal structure of the compound unambiguously proves the structure of the benzimidazolone compound.

Entities: Chemical Disease Gene

Keywords: Benzimidazolone; Confocal microasopy; MTT assay; Palladium catalyzed

Year: 2015 PMID： 26101549 PMCID： PMC4470994 DOI： 10.1007/s12154-015-0130-8

Source DB: PubMed Journal: J Chem Biol ISSN： 1864-6158

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References

28 in total

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Synthesis and cytotoxicity studies of 1-propenyl-1,3-dihydro-benzimidazol-2-one.

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