Amel M Soliman1, Sohair R Fahmy1, Salma A El-Abied2. 1. Zoology Department, Faculty of Science, Cairo University Egypt. 2. Faculty of Science, El-Markb University El Khoms, Libya.
Abstract
OBJECTIVES: With the development of sophisticated instruments for the isolation and elucidation of natural products structures from marine and freshwater organisms, major advances have been made in the discovery of aquatic derived therapeutics. Present investigations were carried out to evaluate cuttlefish (Sepia officinalis) ink extract (IE) and freshwater clam (Coelatura aegyptiaca) extract (CE) for their anticancer and antioxidant activities as compared to 5-flurouracil (5-Fu), in Ehrlich ascites carcinoma (EAC). METHODS: Sixty female Swiss albino mice were divided into five groups (n = 12). All groups except group I received EAC cells (5 × 10(6) cells/mouse i.p.) and this was taken as the 0th day. Group I served as saline control (5 ml/kg 0.9% NaCl w/v p.o). Group II served as EAC control. Rats of groups III, IV and V received IE, CE (200 mg/kg body weight i.p.), and reference drug (5-Fu, 20 mg/kg body weight i.p.), respectively. RESULTS: The reduction in tumor volume, packed cell volume, tumor cell counts and increase in median survival time and percentage increase in life span in treated animals were observed. There was a significant increase in RBC count; Hb content in treated animals and reduction in total WBC count. There was a significant decrease in AST, ALT, ALP and liver MDA levels and increase in GSH, SOD and NO levels were observed in all treated animals. CONCLUSION: Both IE and CE were effective in inhibiting the tumor growth in ascitic tumor models. The biochemical, antioxidants and histopathological studies were also supported their antitumor properties.
OBJECTIVES: With the development of sophisticated instruments for the isolation and elucidation of natural products structures from marine and freshwater organisms, major advances have been made in the discovery of aquatic derived therapeutics. Present investigations were carried out to evaluate cuttlefish (Sepia officinalis) ink extract (IE) and freshwater clam (Coelatura aegyptiaca) extract (CE) for their anticancer and antioxidant activities as compared to 5-flurouracil (5-Fu), in Ehrlich ascites carcinoma (EAC). METHODS: Sixty female Swiss albino mice were divided into five groups (n = 12). All groups except group I received EAC cells (5 × 10(6) cells/mouse i.p.) and this was taken as the 0th day. Group I served as saline control (5 ml/kg 0.9% NaCl w/v p.o). Group II served as EAC control. Rats of groups III, IV and V received IE, CE (200 mg/kg body weight i.p.), and reference drug (5-Fu, 20 mg/kg body weight i.p.), respectively. RESULTS: The reduction in tumor volume, packed cell volume, tumor cell counts and increase in median survival time and percentage increase in life span in treated animals were observed. There was a significant increase in RBC count; Hb content in treated animals and reduction in total WBC count. There was a significant decrease in AST, ALT, ALP and liver MDA levels and increase in GSH, SOD and NO levels were observed in all treated animals. CONCLUSION: Both IE and CE were effective in inhibiting the tumor growth in ascitic tumor models. The biochemical, antioxidants and histopathological studies were also supported their antitumor properties.
Authors: M Sri Balasubashini; S Karthigayan; S T Somasundaram; T Balasubramanian; V Viswanathan; P Raveendran; V P Menon Journal: Bioorg Med Chem Lett Date: 2006-09-26 Impact factor: 2.823
Authors: Patrick Borentain; René Gérolami; Franck Dodero; Marie-Anne Chrestian; Francis Quillichini; Jean Ardissone; Henri Perrimond; Albert Chamlian; André Gérolami Journal: Gastroenterol Clin Biol Date: 2006-02