Alper I Dai1, Seniz Demiryürek2, Sefika Nur Aksoy3, Peren Perk4, Oguzhan Saygili5, Kivanc Güngör5. 1. Division of Pediatric Neurology, Department of Pediatrics, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey. Electronic address: dai.alper@gmail.com. 2. Department of Physiology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey. 3. Department of Biochemistry, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey. 4. Division of Pediatric Neurology, Department of Pediatrics, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey. 5. Department of Ophthalmology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey.
Abstract
BACKGROUND: Retinopathy of prematurity is a proliferative vascular disease affecting premature newborns and occurs during vessel development and maturation. The aim of this study was to evaluate the maternal iron deficiency anemia as possible risk factors associated with the development of retinopathy of prematurity among premature or very low birth weight infants. METHODS: In this study, mothers of 254 infants with retinopathy of prematurity were analyzed retrospectively, and their laboratory results of medical records during pregnancy were reviewed for possible iron deficiency anemia. RESULTS: In a cohort of 254 mothers of premature infants with retinopathy of prematurity, 187 (73.6%) had iron deficiency, while the remaining 67 (26.4%) mothers had no deficiency. Babies born to mothers with iron deficiency anemia with markedly decreased hemoglobin, hematocrit, mean corpuscular volume, serum iron, and ferritin levels were more likely to develop retinopathy of prematurity. CONCLUSIONS: Our results are the first to suggest that maternal iron deficiency is a risk factor for the development of retinopathy of prematurity. Our data suggest that maternal iron supplementation therapy during pregnancy might lower the risk of retinopathy of prematurity.
BACKGROUND:Retinopathy of prematurity is a proliferative vascular disease affecting premature newborns and occurs during vessel development and maturation. The aim of this study was to evaluate the maternal iron deficiency anemia as possible risk factors associated with the development of retinopathy of prematurity among premature or very low birth weight infants. METHODS: In this study, mothers of 254 infants with retinopathy of prematurity were analyzed retrospectively, and their laboratory results of medical records during pregnancy were reviewed for possible iron deficiency anemia. RESULTS: In a cohort of 254 mothers of premature infants with retinopathy of prematurity, 187 (73.6%) had iron deficiency, while the remaining 67 (26.4%) mothers had no deficiency. Babies born to mothers with iron deficiency anemia with markedly decreased hemoglobin, hematocrit, mean corpuscular volume, serum iron, and ferritin levels were more likely to develop retinopathy of prematurity. CONCLUSIONS: Our results are the first to suggest that maternal iron deficiency is a risk factor for the development of retinopathy of prematurity. Our data suggest that maternal iron supplementation therapy during pregnancy might lower the risk of retinopathy of prematurity.
Authors: Sang Jin Kim; Alexander D Port; Ryan Swan; J Peter Campbell; R V Paul Chan; Michael F Chiang Journal: Surv Ophthalmol Date: 2018-04-19 Impact factor: 6.048
Authors: Xuejuan Jiang; Kristina Tarczy-Hornoch; Douglas Stram; Joanne Katz; David S Friedman; James M Tielsch; Saiko Matsumura; Seang-Mei Saw; Paul Mitchell; Kathryn A Rose; Susan A Cotter; Rohit Varma Journal: Ophthalmology Date: 2019-02-26 Impact factor: 12.079
Authors: Hugo G Quezada-Pinedo; Florian Cassel; Liesbeth Duijts; Martina U Muckenthaler; Max Gassmann; Vincent W V Jaddoe; Irwin K M Reiss; Marijn J Vermeulen Journal: Nutrients Date: 2021-06-28 Impact factor: 5.717