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Literature DB >> 26091346

Bending Forks and Wagging Dogs--It's about the DNA 3' Tail.

Abstract

Protecting, reversing, and remodeling stalled replication forks are critical to genome stability and require coordinating DNA replication, remodeling, and repair. In this issue, Kile et al. (2015) find that unexpected HLTF specificity for DNA's 3'-hydroxyl tail helps control these biological functions.

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Year: 2015 PMID： 26091346 PMCID： PMC5356400 DOI： 10.1016/j.molcel.2015.06.005

Source DB: PubMed Journal: Mol Cell ISSN： 1097-2765 Impact factor: 17.970

10 in total

1. Human flap endonuclease structures, DNA double-base flipping, and a unified understanding of the FEN1 superfamily.

Authors: Susan E Tsutakawa; Scott Classen; Brian R Chapados; Andrew S Arvai; L David Finger; Grant Guenther; Christopher G Tomlinson; Peter Thompson; Altaf H Sarker; Binghui Shen; Priscilla K Cooper; Jane A Grasby; John A Tainer
Journal: Cell Date: 2011-04-15 Impact factor: 41.582

Review 2. Double strand binding-single strand incision mechanism for human flap endonuclease: implications for the superfamily.

Authors: Susan E Tsutakawa; John A Tainer
Journal: Mech Ageing Dev Date: 2012-01-08 Impact factor: 5.432

1 in total

Review 1. The helicase-like transcription factor (HLTF) in cancer: loss of function or oncomorphic conversion of a tumor suppressor?

Authors: Ludovic Dhont; Céline Mascaux; Alexandra Belayew
Journal: Cell Mol Life Sci Date: 2016-01 Impact factor: 9.261

1 in total

Bending Forks and Wagging Dogs--It's about the DNA 3' Tail.

1. Human flap endonuclease structures, DNA double-base flipping, and a unified understanding of the FEN1 superfamily.

Review 2. Double strand binding-single strand incision mechanism for human flap endonuclease: implications for the superfamily.

3. HLTF's Ancient HIRAN Domain Binds 3' DNA Ends to Drive Replication Fork Reversal.

4. A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2.

5. Role of double-stranded DNA translocase activity of human HLTF in replication of damaged DNA.

6. Structural basis for FEN-1 substrate specificity and PCNA-mediated activation in DNA replication and repair.

7. Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination.

8. The 3'-flap pocket of human flap endonuclease 1 is critical for substrate binding and catalysis.

9. Mechanism of repair of 5'-topoisomerase II-DNA adducts by mammalian tyrosyl-DNA phosphodiesterase 2.

10. Structural basis for recognition of 5'-phosphotyrosine adducts by Tdp2.

Review 1. The helicase-like transcription factor (HLTF) in cancer: loss of function or oncomorphic conversion of a tumor suppressor?