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Literature DB >> 26085987

Vitreous substitutes: challenges and directions.

Abstract

The natural vitreous body has a fine structure and complex functions. The imitation of the natural vitreous body by vitreous substitutes is a challenging work for both researchers and ophthalmologists. Gases, silicone oil, heavy silicone oil and hydrogels, particularly the former two vitreous substitutes are clinically widely used with certain complications. Those, however, are not real artificial vitreous due to lack of structure and function like the natural vitreous body. This article reviews the situations, challenges, and future directions in the development of vitreous substitutes, particularly the experimental and clinical use of a new artificial foldable capsular vitreous body.

Entities: Chemical Disease

Keywords: artificial vitreous; foldable capsular vitreous body; silicone oil; vitreous substitute

Year: 2015 PMID： 26085987 PMCID： PMC4458642 DOI： 10.3980/j.issn.2222-3959.2015.03.01

Source DB: PubMed Journal: Int J Ophthalmol ISSN： 2222-3959 Impact factor: 1.779

38 in total

1. The biocompatibility of a polyelectrolyte vitreous body substitute on a high resistance in vitro model of the blood-retinal barrier.

Authors: Falko Strotmann; Isabel Wolf; Hans-Joachim Galla
Journal: J Biomater Appl Date: 2012-06-12 Impact factor: 2.646

2. Evaluation of supporting role of a foldable capsular vitreous body with magnetic resonance imaging in the treatment of severe retinal detachment in human eyes.

Authors: R Zhang; T Wang; C Xie; X Lin; Z Jiang; Z Wang; Y Liu; Y Luo; C Long; L He; P Wang; Q Gao
Journal: Eye (Lond) Date: 2011-03-18 Impact factor: 3.775

3. Biocompatibility and retinal support of a foldable capsular vitreous body injected with saline or silicone oil implanted in rabbit eyes.

Authors: Peijuan Wang; Qianying Gao; Zhaoxin Jiang; Jianxian Lin; Yaqin Liu; Jiajia Chen; Lian Zhou; Huaiyang Li; Qingfang Yang; Ting Wang
Journal: Clin Exp Ophthalmol Date: 2011-10-20 Impact factor: 4.207

4. Clinical device-related article evaluation of morphology and functions of a foldable capsular vitreous body in the rabbit eye.

Authors: Jiajia Chen; Qianying Gao; Yaqin Liu; Jian Ge; Xianwu Cao; Yan Luo; Danping Huang; Gege Zhou; Shaofen Lin; Jianxian Lin; Chi Ho To; Andrew W Siu
Journal: J Biomed Mater Res B Appl Biomater Date: 2011-03-25 Impact factor: 3.368

5. The combined use of heavy and light silicone oil in the treatment of complicated retinal detachment with 360º retinal breaks: tamponade effect or filling effect?

Authors: Stefano Zenoni; Natalia Comi; Piero Fontana; Mario R Romano
Journal: Ann Acad Med Singapore Date: 2012-10 Impact factor: 2.473

6. Heavy silicone oil versus standard silicone oil in as vitreous tamponade in inferior PVR (HSO Study): interim analysis.

Authors: Antonia M Joussen; Stanislao Rizzo; Bernd Kirchhof; Norbert Schrage; Xiaoxin Li; Christina Lente; Ralf-Dieter Hilgers
Journal: Acta Ophthalmol Date: 2011-04-07 Impact factor: 3.761

Review 7. Silicone oil induced glaucoma: a review.

Authors: Parul Ichhpujani; Anjana Jindal; L Jay Katz
Journal: Graefes Arch Clin Exp Ophthalmol Date: 2009-08-14 Impact factor: 3.117

8. A new strategy to replace the natural vitreous by a novel capsular artificial vitreous body with pressure-control valve.

Authors: Q Gao; S Mou; J Ge; C-H To; Y Hui; A Liu; Z Wang; C Long; J Tan
Journal: Eye (Lond) Date: 2007-05-25 Impact factor: 3.775

9. Preliminary study on retinal vascular and oxygen-related changes after long-term silicone oil and foldable capsular vitreous body tamponade.

Authors: Wei Yang; Yongguang Yuan; Yao Zong; Zhen Huang; Shuyi Mai; Yujie Li; Xiaobing Qian; Yaqin Liu; Qianying Gao
Journal: Sci Rep Date: 2014-06-12 Impact factor: 4.379

10. Comprehensive analysis of inflammatory immune mediators of the intraocular fluid aspirated from the foldable capsular vitreous body filled-eyes.

Authors: Peijuan Wang; Qianying Gao; Xiaofeng Lin; Shaochong Zhang; Jie Hu; Yaqin Liu; Nuo Xu; Jian Ge
Journal: PLoS One Date: 2012-10-01 Impact factor: 3.240

11 in total

Vitreous substitutes: challenges and directions.

1. The biocompatibility of a polyelectrolyte vitreous body substitute on a high resistance in vitro model of the blood-retinal barrier.

2. Evaluation of supporting role of a foldable capsular vitreous body with magnetic resonance imaging in the treatment of severe retinal detachment in human eyes.

3. Biocompatibility and retinal support of a foldable capsular vitreous body injected with saline or silicone oil implanted in rabbit eyes.

4. Clinical device-related article evaluation of morphology and functions of a foldable capsular vitreous body in the rabbit eye.

5. The combined use of heavy and light silicone oil in the treatment of complicated retinal detachment with 360º retinal breaks: tamponade effect or filling effect?

6. Heavy silicone oil versus standard silicone oil in as vitreous tamponade in inferior PVR (HSO Study): interim analysis.

Review 7. Silicone oil induced glaucoma: a review.

8. A new strategy to replace the natural vitreous by a novel capsular artificial vitreous body with pressure-control valve.

9. Preliminary study on retinal vascular and oxygen-related changes after long-term silicone oil and foldable capsular vitreous body tamponade.

10. Comprehensive analysis of inflammatory immune mediators of the intraocular fluid aspirated from the foldable capsular vitreous body filled-eyes.

1. Intraocular silicone implant to treat chronic ocular hypotony-preliminary feasibility data.

2. Evaluation of the long-term effect of foldable capsular vitreous bodies in severe ocular rupture.

Review 3. Vitreous function and intervention of it with vitrectomy and other modalities.

4. Vitreous function and intervention of it with vitrectomy and other modalities.

Review 5. Peptidomimetics Therapeutics for Retinal Disease.

6. Adenosine for postoperative analgesia: A systematic review and meta-analysis.

7. Ex vivo biophysical characterization of a hydrogel-based artificial vitreous substitute.

8. Study on the effectiveness and safety of Foldable Capsular Vitreous Body implantation.

9. Outcomes of a Foldable Capsular Vitreous Body Implantation: A Retrospective Study.

10. FOLDABLE CAPSULAR VITREOUS BODY IMPLANTATION FOR COMPLICATED RETINAL DETACHMENT CAUSED BY SEVERE OCULAR TRAUMA.