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Literature DB >> 26084957

Stereoselective chlorothiolation of artemisinin-derived C-10 oxa terminal alkynes.

Naresh Surineni¹, Pori Buragohain¹, Nabin C Barua².

Abstract

A mild and efficient strategy is explored on the highly sensitive artemisinin-derived C-10 oxa terminal alkynes. Several novel artemisinin-derived (E)-2-chloroalkenyl sulfides (20) have been synthesized by using this protocol to study their anticancer activities.

Entities: Chemical Gene

Keywords: Alkynes; Artemisinin; Chlorothiolation; Vinyl sulfides

Mesh：

Substances：

Year: 2015 PMID： 26084957 DOI： 10.1007/s11030-015-9607-1

Source DB: PubMed Journal: Mol Divers ISSN： 1381-1991 Impact factor: 2.943

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References

19 in total

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Authors: Christopher P Hencken; Lorraine Jones-Brando; Claudia Bordón; Remo Stohler; Bryan T Mott; Robert Yolken; Gary H Posner; Lauren E Woodard
Journal: J Med Chem Date: 2010-05-13 Impact factor: 7.446

2. Palladium-catalyzed regio- and stereoselective chlorothiolation of terminal alkynes with sulfenyl chlorides.

Authors: Masayuki Iwasaki; Tomoya Fujii; Arisa Yamamoto; Kiyohiko Nakajima; Yasushi Nishihara
Journal: Chem Asian J Date: 2013-11-07

3. Bio-transformation of artemisinin using soil microbe: Direct C-acetoxylation of artemisinin at C-9 by Penicillium simplissimum.

Authors: Abhishek Goswami; Partha P Saikia; Nabin C Barua; Manobjyoti Bordoloi; Archana Yadav; Tarun C Bora; Binod K Gogoi; Ajit Kumar Saxena; Nithasa Suri; Madhunika Sharma
Journal: Bioorg Med Chem Lett Date: 2009-10-29 Impact factor: 2.823

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Authors: H M Gu; B F Lu; Z X Qu
Journal: Zhongguo Yao Li Xue Bao Date: 1980-09

Review 5. Artemisinin and its derivatives: a novel class of anti-malarial and anti-cancer agents.

Authors: Devdutt Chaturvedi; Abhishek Goswami; Partha Pratim Saikia; Nabin C Barua; Paruchuri G Rao
Journal: Chem Soc Rev Date: 2009-08-24 Impact factor: 54.564

6. Vinyl sulfide cyclized analogues of angiotensin II with high affinity and full agonist activity at the AT(1) receptor.

Authors: Petra Johannesson; Gunnar Lindeberg; Anja Johansson; Gregory V Nikiforovich; Adolf Gogoll; Barbro Synnergren; Madeleine Le Grèves; Fred Nyberg; Anders Karlén; Anders Hallberg
Journal: J Med Chem Date: 2002-04-25 Impact factor: 7.446

Stereoselective chlorothiolation of artemisinin-derived C-10 oxa terminal alkynes.

1. Thiazole, oxadiazole, and carboxamide derivatives of artemisinin are highly selective and potent inhibitors of Toxoplasma gondii.

2. Palladium-catalyzed regio- and stereoselective chlorothiolation of terminal alkynes with sulfenyl chlorides.

3. Bio-transformation of artemisinin using soil microbe: Direct C-acetoxylation of artemisinin at C-9 by Penicillium simplissimum.

4. [Antimalarial activities of 25 derivatives of artemisinine against chloroquine-resistant plasmodium berghei (author's transl)].

Review 5. Artemisinin and its derivatives: a novel class of anti-malarial and anti-cancer agents.

6. Vinyl sulfide cyclized analogues of angiotensin II with high affinity and full agonist activity at the AT(1) receptor.

7. Growth inhibition activity of thioacetal artemisinin derivatives against human umbilical vein endothelial cells.

8. Synthesis and antiangiogenic activity of exo-olefinated deoxoartemisinin derivatives.

Review 9. Qinghaosu (artemisinin): an antimalarial drug from China.

10. In vitro activities of the novel cephalosporin LB 11058 against multidrug-resistant Staphylococci and Streptococci.