| Literature DB >> 19913412 |
Abhishek Goswami1, Partha P Saikia, Nabin C Barua, Manobjyoti Bordoloi, Archana Yadav, Tarun C Bora, Binod K Gogoi, Ajit Kumar Saxena, Nithasa Suri, Madhunika Sharma.
Abstract
Potent antimalarial compound artemisinin, 1 was bio-transformed to C-9 acetoxy artemisinin, 2 using soil microbe Penicillium simplissimum along with C-9 hydroxy derivative 3. The products were characterized using high field NMR and MS-MS data. The absolute stereochemistry of the newly generated chiral centers has been ascertained by COSY and 1D NOESY experiments. This is the first Letter of direct C-acetoxylation of artemisinin using microbial strains. Copyright 2009 Elsevier Ltd. All rights reserved.Entities:
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Year: 2009 PMID： 19913412 DOI： 10.1016/j.bmcl.2009.10.097
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823