J A Batsis1,2,3,4, A J Zbehlik2,3,4,5, L K Barre2,3,4, J P W Bynum1,2,3,4, D Pidgeon6, S J Bartels2,3,4. 1. a Section of General Internal Medicine, Dartmouth-Hitchcock Medical Center , Lebanon , NH , USA. 2. b Centers for Health and Aging, Dartmouth College , Lebanon , NH , USA. 3. c Geisel School of Medicine at Dartmouth , Hanover , NH , USA. 4. d The Dartmouth Institute, Dartmouth College , Lebanon , NH , USA. 5. e Section of Rheumatology, Dartmouth-Hitchcock Medical Center , Lebanon , NH , USA. 6. f Department of Physical Medicine and Rehabilitation , Dartmouth-Hitchcock Medical Center , Lebanon , NH , USA.
Abstract
OBJECTIVES: Older adults with obesity are at risk for osteoarthritis (OA) and are predisposed to functional decline and disability. We examined the association between obesity and disability, physical activity, and quality of life at 6 years. METHOD: Using data from the longitudinal Osteoarthritis Initiative (OAI), we analysed older adults (age ≥ 60 years) with a body mass index (BMI) at baseline ≥ 18.5 kg/m(2) (n = 2378) using standard BMI categories. Outcomes were assessed at the 6-year follow-up and included: the Late-Life Function and Disability Index (LLDI), the 12-item Short Form Health Survey (SF-12), and the Physical Activity Scale for the Elderly (PASE). Linear regression predicted outcomes based on BMI category, adjusting for age, sex, race, education, smoking, cohort status, radiographic knee OA, co-morbidity scores, and baseline scores when available. RESULTS: Follow-up data were available for 1727 (71.9%) participants (mean age 67.9 ± 5.3 years; 61.6% female). At baseline, obese subjects compared to overweight and normal were on a greater number of medications (4.28 vs. 3.63 vs. 3.32), had lower gait speeds (1.22 vs. 1.32 vs. 1.36 m/s), higher Charlson scores (0.59 vs. 0.37 vs. 0.30), and higher Western Ontario and McMaster University OA Index (WOMAC) scores (right: 14.8 vs. 10.3 vs. 7.5; left: 14.4 vs. 9.9 vs. 7.5). SF-12 scores at 6 years were lower in obese patients than in overweight or normal [99.5 (95% CI 98.7-100.4) vs. 101.1 (95% CI 100.4-101.8) vs. 102.8 (95% CI 101.8-103.8)], as were PASE scores [115.1 (95% CI 110.3-119.8) vs. 126.2 (95% CI 122.2-130.2) vs. 131.4 (95% CI 125.8-137.0)]. The LLDI limitation component demonstrated differences in obese compared to overweight or normal [78.6 (95% CI 77.4-79.9) vs. 81.2 (95% CI 80.2-82.3) vs. 82.5 (95% CI 81.1-84.0)]. CONCLUSIONS: Obesity was associated with worse physical activity scores, lower quality of life, and higher risk of 6-year disability.
OBJECTIVES: Older adults with obesity are at risk for osteoarthritis (OA) and are predisposed to functional decline and disability. We examined the association between obesity and disability, physical activity, and quality of life at 6 years. METHOD: Using data from the longitudinal Osteoarthritis Initiative (OAI), we analysed older adults (age ≥ 60 years) with a body mass index (BMI) at baseline ≥ 18.5 kg/m(2) (n = 2378) using standard BMI categories. Outcomes were assessed at the 6-year follow-up and included: the Late-Life Function and Disability Index (LLDI), the 12-item Short Form Health Survey (SF-12), and the Physical Activity Scale for the Elderly (PASE). Linear regression predicted outcomes based on BMI category, adjusting for age, sex, race, education, smoking, cohort status, radiographic knee OA, co-morbidity scores, and baseline scores when available. RESULTS: Follow-up data were available for 1727 (71.9%) participants (mean age 67.9 ± 5.3 years; 61.6% female). At baseline, obese subjects compared to overweight and normal were on a greater number of medications (4.28 vs. 3.63 vs. 3.32), had lower gait speeds (1.22 vs. 1.32 vs. 1.36 m/s), higher Charlson scores (0.59 vs. 0.37 vs. 0.30), and higher Western Ontario and McMaster University OA Index (WOMAC) scores (right: 14.8 vs. 10.3 vs. 7.5; left: 14.4 vs. 9.9 vs. 7.5). SF-12 scores at 6 years were lower in obesepatients than in overweight or normal [99.5 (95% CI 98.7-100.4) vs. 101.1 (95% CI 100.4-101.8) vs. 102.8 (95% CI 101.8-103.8)], as were PASE scores [115.1 (95% CI 110.3-119.8) vs. 126.2 (95% CI 122.2-130.2) vs. 131.4 (95% CI 125.8-137.0)]. The LLDI limitation component demonstrated differences in obese compared to overweight or normal [78.6 (95% CI 77.4-79.9) vs. 81.2 (95% CI 80.2-82.3) vs. 82.5 (95% CI 81.1-84.0)]. CONCLUSIONS:Obesity was associated with worse physical activity scores, lower quality of life, and higher risk of 6-year disability.
Authors: Michael D Jensen; Donna H Ryan; Caroline M Apovian; Jamy D Ard; Anthony G Comuzzie; Karen A Donato; Frank B Hu; Van S Hubbard; John M Jakicic; Robert F Kushner; Catherine M Loria; Barbara E Millen; Cathy A Nonas; F Xavier Pi-Sunyer; June Stevens; Victor J Stevens; Thomas A Wadden; Bruce M Wolfe; Susan Z Yanovski; Harmon S Jordan; Karima A Kendall; Linda J Lux; Roycelynn Mentor-Marcel; Laura C Morgan; Michael G Trisolini; Janusz Wnek; Jeffrey L Anderson; Jonathan L Halperin; Nancy M Albert; Biykem Bozkurt; Ralph G Brindis; Lesley H Curtis; David DeMets; Judith S Hochman; Richard J Kovacs; E Magnus Ohman; Susan J Pressler; Frank W Sellke; Win-Kuang Shen; Sidney C Smith; Gordon F Tomaselli Journal: Circulation Date: 2013-11-12 Impact factor: 29.690
Authors: Sari Stenholm; Tamara B Harris; Taina Rantanen; Marjolein Visser; Stephen B Kritchevsky; Luigi Ferrucci Journal: Curr Opin Clin Nutr Metab Care Date: 2008-11 Impact factor: 4.294
Authors: Reva C Lawrence; David T Felson; Charles G Helmick; Lesley M Arnold; Hyon Choi; Richard A Deyo; Sherine Gabriel; Rosemarie Hirsch; Marc C Hochberg; Gene G Hunder; Joanne M Jordan; Jeffrey N Katz; Hilal Maradit Kremers; Frederick Wolfe Journal: Arthritis Rheum Date: 2008-01
Authors: Stephen P Sayers; Alan M Jette; Stephen M Haley; Tim C Heeren; Jack M Guralnik; Roger A Fielding Journal: J Am Geriatr Soc Date: 2004-09 Impact factor: 5.562
Authors: Bo Hu; Søren Thorgaard Skou; Barton L Wise; Glenn N Williams; Michael C Nevitt; Neil A Segal Journal: Arch Phys Med Rehabil Date: 2018-01-31 Impact factor: 3.966
Authors: Joshua F Baker; Jin Long; Mary B Leonard; Tamara Harris; Matthew J Delmonico; Adam Santanasto; Suzanne Satterfield; Babette Zemel; David R Weber Journal: J Gerontol A Biol Sci Med Sci Date: 2018-06-14 Impact factor: 6.053
Authors: Rima Itani Al-Nimr; K C S Wright; Christina L Aquila; Curtis L Petersen; Tyler L Gooding; John A Batsis Journal: Clin Nutr ESPEN Date: 2020-09-19
Authors: John A Batsis; Karen L Whiteman; Matthew C Lohman; Emily A Scherer; Stephen J Bartels Journal: J Rural Health Date: 2017-03-15 Impact factor: 4.333
Authors: Molly W Vaughan; David T Felson; Michael P LaValley; Gael I Orsmond; Jingbo Niu; Cora E Lewis; Neil A Segal; Michael C Nevitt; Julie J Keysor Journal: Arthritis Care Res (Hoboken) Date: 2017-06-02 Impact factor: 4.794
Authors: Matthew S Harkey; Lori Lyn Price; Kieran F Reid; Grace H Lo; Shao-Hsien Liu; Kate L Lapane; Lucas Ogura Dantas; Timothy E McAlindon; Jeffrey B Driban Journal: Clin Rheumatol Date: 2020-02-06 Impact factor: 2.980