Literature DB >> 26082933

Cbl-b: Roles in T Cell Tolerance, Proallergic T Cell Development, and Cancer Immunity.

Jian Zhang1, Qingjun Liu1, Wallace Y Langdon2.   

Abstract

Cbl-b is a member of the Cbl family of RING finger E3 ubiquitin ligases and polymorphisms and mutations in Cbl-b are associated with several autoimmune/inflammatory diseases in humans. Furthermore, gene targeting experiments in mice have provided proof of the in vivo effects of Cbl-b on T cell function and its involvement with these diseases. This brief review updates our understanding of Cbl-b in T cell tolerance, proallergic T cell development, and cancer immunity in light of the most recent advances, and their impact on autoimmune-/inflammatory diseases and cancer immunotherapy.

Entities:  

Keywords:  Cbl-b; NK cells; T cell tolerance; asthma; autoimmunity; cancer; proallergic T cells

Year:  2014        PMID： 26082933      PMCID： PMC4465365          DOI： 10.14800/ics.146

Source DB:  PubMed          Journal:  Inflamm Cell Signal        ISSN： 2330-7803


  27 in total

1.  Variants within the immunoregulatory CBLB gene are associated with multiple sclerosis.

Authors:  Serena Sanna; Maristella Pitzalis; Magdalena Zoledziewska; Ilenia Zara; Carlo Sidore; Raffaele Murru; Michael B Whalen; Fabio Busonero; Andrea Maschio; Gianna Costa; Maria Cristina Melis; Francesca Deidda; Fausto Poddie; Laura Morelli; Gabriele Farina; Yun Li; Mariano Dei; Sandra Lai; Antonella Mulas; Gianmauro Cuccuru; Eleonora Porcu; Liming Liang; Patrizia Zavattari; Loredana Moi; Elisa Deriu; M Francesca Urru; Michele Bajorek; Maria Anna Satta; Eleonora Cocco; Paola Ferrigno; Stefano Sotgiu; Maura Pugliatti; Sebastiano Traccis; Andrea Angius; Maurizio Melis; Giulio Rosati; Gonçalo R Abecasis; Manuela Uda; Maria Giovanna Marrosu; David Schlessinger; Francesco Cucca
Journal:  Nat Genet       Date:  2010-05-09       Impact factor: 38.330

2.  E3 ubiquitin ligase Cbl-b regulates Pten via Nedd4 in T cells independently of its ubiquitin ligase activity.

Authors:  Hui Guo; Guilin Qiao; Haiyan Ying; Zhenping Li; Yixia Zhao; Yanran Liang; Lifen Yang; Stanley Lipkowitz; Josef M Penninger; Wallace Y Langdon; Jian Zhang
Journal:  Cell Rep       Date:  2012-05-31       Impact factor: 9.423

3.  Abrogating Cbl-b in effector CD8(+) T cells improves the efficacy of adoptive therapy of leukemia in mice.

Authors:  Ingunn M Stromnes; Joseph N Blattman; Xiaoxia Tan; Sara Jeevanjee; Hua Gu; Philip D Greenberg
Journal:  J Clin Invest       Date:  2010-09-20       Impact factor: 14.808

4.  Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b.

Authors:  K Bachmaier; C Krawczyk; I Kozieradzki; Y Y Kong; T Sasaki; A Oliveira-dos-Santos; S Mariathasan; D Bouchard; A Wakeham; A Itie; J Le; P S Ohashi; I Sarosi; H Nishina; S Lipkowitz; J M Penninger
Journal:  Nature       Date:  2000-01-13       Impact factor: 49.962

Review 5.  c-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signalling responses.

Authors:  Christine B F Thien; Wallace Y Langdon
Journal:  Biochem J       Date:  2005-10-15       Impact factor: 3.857

6.  T cell activation threshold regulated by E3 ubiquitin ligase Cbl-b determines fate of inducible regulatory T cells.

Authors:  Guilin Qiao; Yixia Zhao; Zhenping Li; Peter Q Tang; Wallace Y Langdon; Tianlan Yang; Jian Zhang
Journal:  J Immunol       Date:  2013-06-07       Impact factor: 5.422

7.  Cutting edge: CTLA-4--B7 interaction suppresses Th17 cell differentiation.

Authors:  Haiyan Ying; Lifen Yang; Guilin Qiao; Zhenping Li; Li Zhang; Fei Yin; Dong Xie; Jian Zhang
Journal:  J Immunol       Date:  2010-07-02       Impact factor: 5.422

8.  TCR affinity and negative regulation limit autoimmunity.

Authors:  Matthew A Gronski; Jonathan M Boulter; Demetrius Moskophidis; Linh T Nguyen; Kaisa Holmberg; Alisha R Elford; Elissa K Deenick; Hee O Kim; Josef M Penninger; Bernhard Odermatt; Awen Gallimore; Nicholas R J Gascoigne; Pamela S Ohashi
Journal:  Nat Med       Date:  2004-10-03       Impact factor: 53.440

9.  Ablation of Cbl-b provides protection against transplanted and spontaneous tumors.

Authors:  Jeffrey Y Chiang; Ihn Kyung Jang; Richard Hodes; Hua Gu
Journal:  J Clin Invest       Date:  2007-03-15       Impact factor: 14.808

10.  The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells.

Authors:  Magdalena Paolino; Axel Choidas; Stephanie Wallner; Blanka Pranjic; Iris Uribesalgo; Stefanie Loeser; Amanda M Jamieson; Wallace Y Langdon; Fumiyo Ikeda; Juan Pablo Fededa; Shane J Cronin; Roberto Nitsch; Carsten Schultz-Fademrecht; Jan Eickhoff; Sascha Menninger; Anke Unger; Robert Torka; Thomas Gruber; Reinhard Hinterleitner; Gottfried Baier; Dominik Wolf; Axel Ullrich; Bert M Klebl; Josef M Penninger
Journal:  Nature       Date:  2014-02-19       Impact factor: 49.962
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  2 in total

1.  The Csk-Associated Adaptor PAG Inhibits Effector T Cell Activation in Cooperation with Phosphatase PTPN22 and Dok Adaptors.

Authors:  Dominique Davidson; Ming-Chao Zhong; Pier Paolo Pandolfi; Silvia Bolland; Ramnik J Xavier; Brian Seed; Xin Li; Hua Gu; André Veillette
Journal:  Cell Rep       Date:  2016-12-06       Impact factor: 9.423

Review 2.  Translational utility of experimental autoimmune encephalomyelitis: recent developments.

Authors:  Andre Ortlieb Guerreiro-Cacais; Hannes Laaksonen; Sevasti Flytzani; Marie N'diaye; Tomas Olsson; Maja Jagodic
Journal:  J Inflamm Res       Date:  2015-11-13
  2 in total

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