Kangan Li1,2,3, Andrew C Gordon2, Linfeng Zheng1,2,3, Weiguo Li2, Yang Guo2, Jing Sun2, Guixiang Zhang1, Guohong Han4, Andrew C Larson2,3, Zhuoli Zhang2,3. 1. Department of Radiology, Shanghai First People's Hospital, Shanghai Jiaotong University, Shanghai 200080, P. R. China. 2. Departments of Radiology, Northwestern University, 737 N Michigan Ave, Suite 1600, Chicago, IL 60611, USA. 3. Robert H. Lurie Comprehensive Cancer Center, 675 N St Clair, 21st Floor, Suite 100, Chicago, IL 60611, USA. 4. Department of Liver Disease & Digestive Interventional Radiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
Abstract
AIM: To test the hypothesis that MRI can monitor intraportal vein (IPV) transcatheter delivery of clinically applicable heparin-protamine-ferumoxytol (HPF) nanocomplex-labeled natural killer (NK) cells to liver tumor. MATERIALS & METHODS: Liver tumor rat models underwent catheterization for IPV infusion of HPF-labeled NK cells (NK-92MI cell line). MRI measurements within tumor and adjacent liver tissues were compared pre- and post-NK cell infusion. Histology studies were used to identify NK cells in the target tumors. RESULTS: For first time, we demonstrated that MRI tracks HPF-labeled NK cells migration within liver following IPV delivery. CONCLUSION: IPV transcatheter infusion permitted selective delivery of NK cells to liver tissues and MRI allowed tracking NK cell biodistributions within the tumors.
AIM: To test the hypothesis that MRI can monitor intraportal vein (IPV) transcatheter delivery of clinically applicable heparin-protamine-ferumoxytol (HPF) nanocomplex-labeled natural killer (NK) cells to liver tumor. MATERIALS & METHODS:Liver tumorrat models underwent catheterization for IPV infusion of HPF-labeled NK cells (NK-92MI cell line). MRI measurements within tumor and adjacent liver tissues were compared pre- and post-NK cell infusion. Histology studies were used to identify NK cells in the target tumors. RESULTS: For first time, we demonstrated that MRI tracks HPF-labeled NK cells migration within liver following IPV delivery. CONCLUSION:IPV transcatheter infusion permitted selective delivery of NK cells to liver tissues and MRI allowed tracking NK cell biodistributions within the tumors.
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