| Literature DB >> 26077826 |
Fangchen Gong1, Zhengxia Liu1, Jingning Liu1, Ping Zhou1, Ying Liu1, Xiang Lu2.
Abstract
Atherosclerosis is a chronic inflammatory disease mediated by innate and adaptive immune responses. In recent years, CD4(+) T cells (Th1, Th2, Treg, and Th17) have been increasingly studied for their role in atherosclerosis pathophysiology, atheroma stability, plaque rupture, and life-threatening acute coronary syndrome. IL-17, a marker cytokine of Th17 cells, has been reported to be involved in the pathogenesis of rheumatoid arthritis, inflammatory bowel disease, and asthma. However, its role in atherosclerosis has been poorly characterized. This article provides a comprehensive overview of the role of IL-17 in the development of atherosclerosis and human coronary artery diseases.Entities:
Keywords: Atherosclerosis; Coronary artery disease; IL-17; Immunity
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Year: 2015 PMID： 26077826 DOI： 10.1016/j.cellimm.2015.05.007
Source DB: PubMed Journal: Cell Immunol ISSN： 0008-8749 Impact factor: 4.868