Hyun Suk Yang1, Hyun Jeong Kim2, Hyoung Joon Shim1, Sun Jong Kim3, Mina Hur4, Salvatore Di Somma5. 1. Department of Cardiovascular Medicine, Konkuk University School of Medicine, Seoul, Korea. 2. Department of Laboratory Medicine, Konkuk University School of Medicine, Seoul, Korea. 3. Department of Respiratory Medicine, Konkuk University School of Medicine, Seoul, Korea. 4. Department of Laboratory Medicine, Konkuk University School of Medicine, Seoul, Korea. Electronic address: dearmina@hanmail.net. 5. Department of Medical-Surgery Sciences and Translational Medicine, University La Sapienza Rome, Sant'Andrea Hospital, Rome, Italy.
Abstract
OBJECTIVE: Stress cardiomyopathy (SCM) sometimes develops in patients with non-cardiac medical illness. We hypothesized that soluble suppression of tumorigenicity 2 (sST2) can predict SCM. METHODS: In 76 patients admitted to non-cardiac medical intensive care unit (MICU), echocardiography and sST2 were assessed on admission day (D0) and on the third day (D2). Cardiac troponin I (cTnI) and B-type natriuretic peptide (BNP) were measured on D0. RESULTS: The SCM group (21%, 16/76) showed significantly higher cTnI, BNP, sST2 (D2), and sST2 changes than the non-SCM group. In receiver operator characteristics curve analysis, they equally predicted SCM. In 65 patients with normal cTnI, sST2 (D2) and sST2 changes predicted SCM better than cTnI or BNP. CONCLUSION: Follow-up sST2 and the change in sST2 have additional predictive value for SCM in patients with normal cTnI. A combination strategy of sST2 and cTnI would be useful to predict SCM in patients admitted to the MICU.
OBJECTIVE:Stress cardiomyopathy (SCM) sometimes develops in patients with non-cardiac medical illness. We hypothesized that soluble suppression of tumorigenicity 2 (sST2) can predict SCM. METHODS: In 76 patients admitted to non-cardiac medical intensive care unit (MICU), echocardiography and sST2 were assessed on admission day (D0) and on the third day (D2). Cardiac troponin I (cTnI) and B-type natriuretic peptide (BNP) were measured on D0. RESULTS: The SCM group (21%, 16/76) showed significantly higher cTnI, BNP, sST2 (D2), and sST2 changes than the non-SCM group. In receiver operator characteristics curve analysis, they equally predicted SCM. In 65 patients with normal cTnI, sST2 (D2) and sST2 changes predicted SCM better than cTnI or BNP. CONCLUSION: Follow-up sST2 and the change in sST2 have additional predictive value for SCM in patients with normal cTnI. A combination strategy of sST2 and cTnI would be useful to predict SCM in patients admitted to the MICU.
Authors: Timothy P Fitzgibbons; Yvonne J K Edwards; Peter Shaw; Aline Iskandar; Mohamed Ahmed; Josiah Bote; Tejen Shah; Sumita Sinha; Robert E Gerszten; John F Keaney; Michael R Zile; Gerard P Aurigemma Journal: Front Cardiovasc Med Date: 2017-08-03
Authors: Hyun Suk Yang; Mina Hur; Hanah Kim; Laura Magrini; Rossella Marino; Salvatore Di Somma Journal: Ann Lab Med Date: 2016-11 Impact factor: 3.464