Literature DB >> 2607354

Isolation and characterization of an antimalarial agent of the neem tree Azadirachta indica.

S A Khalid1, H Duddeck, M Gonzalez-Sierra.   

Abstract

The isolation and structure elucidation of gedunin [1], the antimalarial agent of Azadirachta indica, are reported. Its 1H- and 13C-nmr spectra were assigned by using one- and two-dimensional nmr spectroscopy, especially homonuclear and heteronuclear COSY, nOe difference, and COLOC experiments.

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Year:  1989        PMID： 2607354     DOI： 10.1021/np50065a002

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  17 in total

1.  Nimbolide sensitizes human colon cancer cells to TRAIL through reactive oxygen species- and ERK-dependent up-regulation of death receptors, p53, and Bax.

Authors:  Subash C Gupta; Simone Reuter; Kanokkarn Phromnoi; Byoungduck Park; Padmanabhan S Hema; Mangalam Nair; Bharat B Aggarwal
Journal:  J Biol Chem       Date:  2010-11-15       Impact factor: 5.157

2.  In vivo antimalarial evaluation of MAMA decoction on Plasmodium berghei in mice.

Authors:  Awodayo O Adepiti; Anthony A Elujoba; Oluseye O Bolaji
Journal:  Parasitol Res       Date:  2013-11-22       Impact factor: 2.289

3.  Modification of cysteine 179 of IkappaBalpha kinase by nimbolide leads to down-regulation of NF-kappaB-regulated cell survival and proliferative proteins and sensitization of tumor cells to chemotherapeutic agents.

Authors:  Subash C Gupta; Sahdeo Prasad; Simone Reuter; Ramaswamy Kannappan; Vivek R Yadav; Jayaraj Ravindran; Padmanabhan S Hema; Madan M Chaturvedi; Mangalam Nair; Bharat B Aggarwal
Journal:  J Biol Chem       Date:  2010-09-09       Impact factor: 5.157

4.  Gedunin, a novel hsp90 inhibitor: semisynthesis of derivatives and preliminary structure-activity relationships.

Authors:  Gary E L Brandt; Matthew D Schmidt; Thomas E Prisinzano; Brian S J Blagg
Journal:  J Med Chem       Date:  2008-09-25       Impact factor: 7.446

5.  Influence of formulation ratio of the plant components on the antimalarial properties of MAMA decoction.

Authors:  Samuel Akintunde Odediran; Anthony Adebolu Elujoba; Adeleke Clement Adebajo
Journal:  Parasitol Res       Date:  2014-05       Impact factor: 2.289

6.  Deoxygedunin, a natural product with potent neurotrophic activity in mice.

Authors:  Sung-Wuk Jang; Xia Liu; Chi Bun Chan; Stefan A France; Iqbal Sayeed; Wenxue Tang; Xi Lin; Ge Xiao; Raul Andero; Qiang Chang; Kerry J Ressler; Keqiang Ye
Journal:  PLoS One       Date:  2010-07-13       Impact factor: 3.240

Review 7.  Novel small molecule activators of the Trk family of receptor tyrosine kinases.

Authors:  Obiamaka Obianyo; Keqiang Ye
Journal:  Biochim Biophys Acta       Date:  2012-09-06

Review 8.  Natural product inhibitors of Hsp90: potential leads for drug discovery.

Authors:  M W Amolins; B S J Blagg
Journal:  Mini Rev Med Chem       Date:  2009-02       Impact factor: 3.862

9.  Nimbolide, a limonoid triterpene, inhibits growth of human colorectal cancer xenografts by suppressing the proinflammatory microenvironment.

Authors:  Subash C Gupta; Sahdeo Prasad; Dhanya R Sethumadhavan; Mangalam S Nair; Yin-Yuan Mo; Bharat B Aggarwal
Journal:  Clin Cancer Res       Date:  2013-06-13       Impact factor: 12.531

10.  Gedunin- and Khivorin-Derivatives Are Small-Molecule Partial Agonists for Adhesion G Protein-Coupled Receptors GPR56/ADGRG1 and GPR114/ADGRG5.

Authors:  Hannah M Stoveken; Scott D Larsen; Alan V Smrcka; Gregory G Tall
Journal:  Mol Pharmacol       Date:  2018-02-23       Impact factor: 4.436
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