Literature DB >> 2607353

A simple conversion of artemisinic acid into artemisinin.

R J Roth1, N Acton.   

Abstract

Artemisinic acid [1] has been converted into artemisinin [3] in 2 steps via reduction of the exocyclic methylene group and photooxidation of the resulting dihydroartemisinic acid [2].

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Year:  1989        PMID： 2607353     DOI： 10.1021/np50065a050

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  14 in total

Review 1.  The biosynthesis of artemisinin (Qinghaosu) and the phytochemistry of Artemisia annua L. (Qinghao).

Authors:  Geoffrey D Brown
Journal:  Molecules       Date:  2010-10-28       Impact factor: 4.411

Review 2.  The re-emergence of natural products for drug discovery in the genomics era.

Authors:  Alan L Harvey; RuAngelie Edrada-Ebel; Ronald J Quinn
Journal:  Nat Rev Drug Discov       Date:  2015-01-23       Impact factor: 84.694

3.  Applying green chemistry to the photochemical route to artemisinin.

Authors:  Zacharias Amara; Jessica F B Bellamy; Raphael Horvath; Samuel J Miller; Andrew Beeby; Andreas Burgard; Kai Rossen; Martyn Poliakoff; Michael W George
Journal:  Nat Chem       Date:  2015-05-11       Impact factor: 24.427

Review 4.  Semi-synthetic artemisinin: a model for the use of synthetic biology in pharmaceutical development.

Authors:  Chris J Paddon; Jay D Keasling
Journal:  Nat Rev Microbiol       Date:  2014-04-01       Impact factor: 60.633

Review 5.  Recent advances towards development and commercialization of plant cell culture processes for the synthesis of biomolecules.

Authors:  Sarah A Wilson; Susan C Roberts
Journal:  Plant Biotechnol J       Date:  2011-11-08       Impact factor: 9.803

Review 6.  Artemisia annua L.: a source of novel antimalarial drugs.

Authors:  H J Woerdenbag; C B Lugt; N Pras
Journal:  Pharm Weekbl Sci       Date:  1990-10-19

Review 7.  Recent advances in artemisinin production through heterologous expression.

Authors:  Patrick R Arsenault; Kristin K Wobbe; Pamela J Weathers
Journal:  Curr Med Chem       Date:  2008       Impact factor: 4.530

Review 8.  Synthetic biology approaches in drug discovery and pharmaceutical biotechnology.

Authors:  Heinz Neumann; Petra Neumann-Staubitz
Journal:  Appl Microbiol Biotechnol       Date:  2010-04-16       Impact factor: 4.813

9.  High-level semi-synthetic production of the potent antimalarial artemisinin.

Authors:  C J Paddon; P J Westfall; D J Pitera; K Benjamin; K Fisher; D McPhee; M D Leavell; A Tai; A Main; D Eng; D R Polichuk; K H Teoh; D W Reed; T Treynor; J Lenihan; M Fleck; S Bajad; G Dang; D Dengrove; D Diola; G Dorin; K W Ellens; S Fickes; J Galazzo; S P Gaucher; T Geistlinger; R Henry; M Hepp; T Horning; T Iqbal; H Jiang; L Kizer; B Lieu; D Melis; N Moss; R Regentin; S Secrest; H Tsuruta; R Vazquez; L F Westblade; L Xu; M Yu; Y Zhang; L Zhao; J Lievense; P S Covello; J D Keasling; K K Reiling; N S Renninger; J D Newman
Journal:  Nature       Date:  2013-04-10       Impact factor: 49.962

10.  Triterpenoid biosynthesis and engineering in plants.

Authors:  Satoru Sawai; Kazuki Saito
Journal:  Front Plant Sci       Date:  2011-06-30       Impact factor: 5.753
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