Kyung Hwa Jung1, Stephanie Lovinsky-Desir2, Matthew Perzanowski3, Xinhua Liu4, Christina Maher5, Eric Gil6, David Torrone7, Andreas Sjodin8, Zheng Li9, Frederica P Perera10, Rachel L Miller11. 1. Division of Pulmonary, Allergy and Critical Care of Medicine, Department of Medicine, College of Physicians and Surgeons, Columbia University, PH8E-101, 630 W. 168 Street, New York, NY 10032, United States. Electronic address: kj2237@cumc.columbia.edu. 2. Division of Pediatric Pulmonary, Department of Pediatrics, College of Physicians and Surgeons, Columbia University, 3959 Broadway, CHC 7-745, New York, NY 10032, United States. Electronic address: sl3230@cumc.columbia.edu. 3. Mailman School of Public Health, Department of Environmental Health Sciences, Columbia University, 722 W. 168 Street, New York, NY 10032, United States. Electronic address: mp2217@columbia.edu. 4. Mailman School of Public Health, Department of Biostatistics, Columbia University, 722W. 168 Street, New York, NY 10032, United States. Electronic address: xl26@columbia.edu. 5. Division of Pulmonary, Allergy and Critical Care of Medicine, Department of Medicine, College of Physicians and Surgeons, Columbia University, PH8E-101, 630 W. 168 Street, New York, NY 10032, United States. Electronic address: cem2184@cumc.columbia.edu. 6. Division of Pulmonary, Allergy and Critical Care of Medicine, Department of Medicine, College of Physicians and Surgeons, Columbia University, PH8E-101, 630 W. 168 Street, New York, NY 10032, United States. Electronic address: eng2113@cumc.columbia.edu. 7. Division of Pulmonary, Allergy and Critical Care of Medicine, Department of Medicine, College of Physicians and Surgeons, Columbia University, PH8E-101, 630 W. 168 Street, New York, NY 10032, United States. Electronic address: dt2339@cumc.columbia.edu. 8. Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Laboratory Sciences, Organic Analytical Toxicology Branch, Atlanta, GA, United States. Electronic address: zrq4@cdc.gov. 9. Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Laboratory Sciences, Organic Analytical Toxicology Branch, Atlanta, GA, United States. Electronic address: kzl4@cdc.gov. 10. Mailman School of Public Health, Department of Environmental Health Sciences, Columbia University, 722 W. 168 Street, New York, NY 10032, United States. Electronic address: fpp1@columbia.edu. 11. Division of Pulmonary, Allergy and Critical Care of Medicine, Department of Medicine, College of Physicians and Surgeons, Columbia University, PH8E-101, 630 W. 168 Street, New York, NY 10032, United States; Mailman School of Public Health, Department of Environmental Health Sciences, Columbia University, 722 W. 168 Street, New York, NY 10032, United States; Division of Pediatric Allergy, Immunology and Rheumatology, Department of Pediatrics, College of Physicians and Surgeons, Columbia University, PH8E-101, 630 W. 168 Street, New York, NY 10032, United States. Electronic address: rlm14@cumc.columbia.edu.
Abstract
BACKGROUND: Exposures to traffic-related air pollutants including polycyclic aromatic hydrocarbons (PAH) have been associated with the development and exacerbation of asthma. However, there is limited evidence on whether these pollutants are associated with the development of cockroach sensitization, a strong risk factor for urban asthma. We hypothesized that repeatedly high PAH exposure during childhood would be associated with increased risk of new cockroach sensitization. METHODS: As part of the research being conducted by the Columbia Center for Children's Environmental Health (CCCEH) birth cohort study in New York, a spot urine sample was collected from children at age 5 years (2003-2008) and again at age 9-10 years (2008-2012; n=248) and analyzed for 10 PAH metabolites. Repeatedly high PAH (High-High) exposure was defined as measures above median for age 5 PAH metabolites at both time points. Child blood samples at age 5 and 9 years were analyzed for total, anti-cockroach, mouse, dust mite, cat and dog IgE. Relative risks (RR) were estimated with multivariable modified Poisson regression. RESULTS: Individual PAH metabolite levels, except for 1-naphthol (1-OH-NAP), increased by 10-60% from age 5 to age 9-10. The prevalence of cockroach sensitization increased from 17.6% (33/188) at age 5 to 33.0% (62/188) at 9 years (p=0.001). After controlling for potential covariates including cockroach sensitization at age 5 in regression analyses, positive associations were found between repeatedly high exposure (High-High) to 1-OH-NAP, 3-hydroxyphenanthrene (3-OH-PHEN), or 1-hydroxypyrene (1-OH-PYR) and cockroach sensitization at age 9 (p-values<0.05). Compared to Low-Low exposure, the relative risk (RR) [95% CI] with repeatedly high exposure was 1.83 [1.06-3.17] for 1-OH-NAP, 1.54 [1.06-2.23] for 3-OH-PHEN, and 1.59 [1.04-2.43] for 1-OH-PYR. CONCLUSIONS: Repeatedly high levels of urinary PAH metabolites during childhood may increase likelihood of sensitization to cockroach allergen in urban inner-city children at age 9 years.
BACKGROUND: Exposures to traffic-related air pollutants including polycyclic aromatic hydrocarbons (PAH) have been associated with the development and exacerbation of asthma. However, there is limited evidence on whether these pollutants are associated with the development of cockroach sensitization, a strong risk factor for urban asthma. We hypothesized that repeatedly high PAH exposure during childhood would be associated with increased risk of new cockroach sensitization. METHODS: As part of the research being conducted by the Columbia Center for Children's Environmental Health (CCCEH) birth cohort study in New York, a spot urine sample was collected from children at age 5 years (2003-2008) and again at age 9-10 years (2008-2012; n=248) and analyzed for 10 PAH metabolites. Repeatedly high PAH (High-High) exposure was defined as measures above median for age 5 PAH metabolites at both time points. Child blood samples at age 5 and 9 years were analyzed for total, anti-cockroach, mouse, dust mite, cat and dogIgE. Relative risks (RR) were estimated with multivariable modified Poisson regression. RESULTS: Individual PAH metabolite levels, except for 1-naphthol (1-OH-NAP), increased by 10-60% from age 5 to age 9-10. The prevalence of cockroach sensitization increased from 17.6% (33/188) at age 5 to 33.0% (62/188) at 9 years (p=0.001). After controlling for potential covariates including cockroach sensitization at age 5 in regression analyses, positive associations were found between repeatedly high exposure (High-High) to 1-OH-NAP, 3-hydroxyphenanthrene (3-OH-PHEN), or 1-hydroxypyrene (1-OH-PYR) and cockroach sensitization at age 9 (p-values<0.05). Compared to Low-Low exposure, the relative risk (RR) [95% CI] with repeatedly high exposure was 1.83 [1.06-3.17] for 1-OH-NAP, 1.54 [1.06-2.23] for 3-OH-PHEN, and 1.59 [1.04-2.43] for 1-OH-PYR. CONCLUSIONS: Repeatedly high levels of urinary PAH metabolites during childhood may increase likelihood of sensitization to cockroach allergen in urban inner-city children at age 9 years.
Authors: M Brauer; G Hoek; H A Smit; J C de Jongste; J Gerritsen; D S Postma; M Kerkhof; B Brunekreef Journal: Eur Respir J Date: 2007-01-24 Impact factor: 16.671
Authors: Zheng Li; Lovisa C Romanoff; Debra A Trinidad; Erin N Pittman; Donald Hilton; Kendra Hubbard; Hasan Carmichael; Jonathan Parker; Antonia M Calafat; Andreas Sjödin Journal: Anal Bioanal Chem Date: 2014-04-09 Impact factor: 4.142
Authors: Päivi M Salo; Samuel J Arbes; Renee Jaramillo; Agustin Calatroni; Charles H Weir; Michelle L Sever; Jane A Hoppin; Kathryn M Rose; Andrew H Liu; Peter J Gergen; Herman E Mitchell; Darryl C Zeldin Journal: J Allergy Clin Immunol Date: 2014-02-09 Impact factor: 10.793
Authors: Ulrike Gehring; Alet H Wijga; Michael Brauer; Paul Fischer; Johan C de Jongste; Marjan Kerkhof; Marieke Oldenwening; Henriette A Smit; Bert Brunekreef Journal: Am J Respir Crit Care Med Date: 2009-12-03 Impact factor: 21.405
Authors: Kathleen M Donohue; Umaima Al-alem; Matthew S Perzanowski; Ginger L Chew; Alina Johnson; Adnan Divjan; Elizabeth A Kelvin; Lori A Hoepner; Frederica P Perera; Rachel L Miller Journal: J Allergy Clin Immunol Date: 2008-11 Impact factor: 10.793
Authors: Anna Pomés; Geoffrey A Mueller; Thomas A Randall; Martin D Chapman; L Karla Arruda Journal: Curr Allergy Asthma Rep Date: 2017-04 Impact factor: 4.806
Authors: Stephanie Lovinsky-Desir; Kyung Hwa Jung; Andrew G Rundle; Lori A Hoepner; Joshua B Bautista; Frederica P Perera; Steven N Chillrud; Matthew S Perzanowski; Rachel L Miller Journal: Environ Res Date: 2016-09-29 Impact factor: 6.498
Authors: Zeynab Tabatabaei; Narges Shamsedini; Amin Mohammadpour; Mohammad Ali Baghapour; Mohammad Hoseini Journal: Environ Sci Pollut Res Int Date: 2022-05-11 Impact factor: 5.190
Authors: Kyung Hwa Jung; Stephanie Lovinsky-Desir; Beizhan Yan; David Torrone; Jennifer Lawrence; Jacqueline R Jezioro; Matthew Perzanowski; Frederica P Perera; Steven N Chillrud; Rachel L Miller Journal: Clin Epigenetics Date: 2017-06-02 Impact factor: 6.551
Authors: Kyung Hwa Jung; Kathleen E Goodwin; Matthew S Perzanowski; Steven N Chillrud; Frederica P Perera; Rachel L Miller; Stephanie Lovinsky-Desir Journal: Environ Health Perspect Date: 2021-09-08 Impact factor: 9.031