Anna Pomés1, Geoffrey A Mueller2, Thomas A Randall3, Martin D Chapman4, L Karla Arruda5. 1. Indoor Biotechnologies, Inc., 700 Harris Street, Charlottesville, VA, 22903, USA. apomes@inbio.com. 2. Genome Integrity and Structural Biology Laboratory, Intramural Program, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T.W. Alexander Drive, MD-MR01, Research Triangle Park, NC, 27709, USA. 3. Integrative Bioinformatics, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T.W. Alexander Drive, MD-MR01, Research Triangle Park, NC, 27709, USA. 4. Indoor Biotechnologies, Inc., 700 Harris Street, Charlottesville, VA, 22903, USA. 5. Department of Medicine, Ribeirao Preto Medical School, University of Sao Paulo, Av. Bandeirantes 3900, Ribeirao Preto, SP, 14049-900, Brazil.
Abstract
PURPOSE OF REVIEW: This review addresses the most recent developments on cockroach allergen research in relation to allergic diseases, especially asthma. RECENT FINDINGS: The number of allergens relevant to cockroach allergy has recently expanded considerably up to 12 groups. New X-ray crystal structures of allergens from groups 1, 2, and 5 revealed interesting features with implications for allergen standardization, sensitization, diagnosis, and therapy. Cockroach allergy is strongly associated with asthma particularly among children and young adults living in inner-city environments, posing challenges for disease control. Environmental interventions targeted at reducing cockroach allergen exposure have provided conflicting results. Immunotherapy may be a way to modify the natural history of cockroach allergy and decrease symptoms and asthma severity among sensitized and exposed individuals. The new information on cockroach allergens is important for the assessment of allergen markers of exposure and disease, and for the design of immunotherapy trials.
PURPOSE OF REVIEW: This review addresses the most recent developments on cockroach allergen research in relation to allergic diseases, especially asthma. RECENT FINDINGS: The number of allergens relevant to cockroach allergy has recently expanded considerably up to 12 groups. New X-ray crystal structures of allergens from groups 1, 2, and 5 revealed interesting features with implications for allergen standardization, sensitization, diagnosis, and therapy. Cockroach allergy is strongly associated with asthma particularly among children and young adults living in inner-city environments, posing challenges for disease control. Environmental interventions targeted at reducing cockroach allergen exposure have provided conflicting results. Immunotherapy may be a way to modify the natural history of cockroach allergy and decrease symptoms and asthma severity among sensitized and exposed individuals. The new information on cockroach allergens is important for the assessment of allergen markers of exposure and disease, and for the design of immunotherapy trials.
Authors: Edward M Zoratti; Rebecca Z Krouse; Denise C Babineau; Jacqueline A Pongracic; George T O'Connor; Robert A Wood; Gurjit K Khurana Hershey; Carolyn M Kercsmar; Rebecca S Gruchalla; Meyer Kattan; Stephen J Teach; Steven M Sigelman; Peter J Gergen; Alkis Togias; Cynthia M Visness; William W Busse; Andrew H Liu Journal: J Allergy Clin Immunol Date: 2016-10 Impact factor: 10.793
Authors: Kristen Page; Valerie S Hughes; Kelli K Odoms; Katherine E Dunsmore; Marc B Hershenson Journal: Am J Respir Cell Mol Biol Date: 2004-12-02 Impact factor: 6.914
Authors: Jorgete M Silva; Ataide A Camara; Kátia R C Tobias; Izolete S Macedo; M Regina A Cardoso; Eurico Arruda; Martin D Chapman; Thomas A E Platts-Mills; L Karla Arruda; Virgínia P L Ferriani Journal: Pediatr Allergy Immunol Date: 2005-08 Impact factor: 6.377
Authors: Xiao Na Ge; Idil Bastan; Mythili Dileepan; Yana Greenberg; Sung Gil Ha; Kaylee A Steen; David A Bernlohr; Savita P Rao; P Sriramarao Journal: Am J Physiol Lung Cell Mol Physiol Date: 2018-04-26 Impact factor: 5.464
Authors: Maksymilian Chruszcz; Fook Tim Chew; Karin Hoffmann-Sommergruber; Barry K Hurlburt; Geoffrey A Mueller; Anna Pomés; Juha Rouvinen; Mayte Villalba; Birgitta M Wöhrl; Heimo Breiteneder Journal: Allergy Date: 2021-05-02 Impact factor: 14.710