Jessica Chorostecki1, Navid Seraji-Bozorgzad1, Aashka Shah1, Fen Bao1, Ginny Bao1, Edwin George2, Veronica Gorden2, Christina Caon1, Elliot Frohman3, M Tariq Bhatti4, Omar Khan5. 1. Sastry Foundation Advanced Imaging Laboratory, Detroit, United States. 2. Movement Disorders Center, Department of Neurology, Wayne State University School of Medicine, Detroit, United States. 3. Department of Neurology, University of Texas Southwestern, Dallas, United States. 4. Department of Ophthalmology, Duke Eye Center and Duke University Medical Center, Durham, United States; Department of Neurology, Duke Eye Center and Duke University Medical Center, Durham, United States. 5. Sastry Foundation Advanced Imaging Laboratory, Detroit, United States. Electronic address: okhan@med.wayne.edu.
Abstract
BACKGROUND: Parkinson's disease (PD) is a neurodegenerative disorder associated with dopaminergic cell loss and α-synuclein aggregation in Lewy bodies, which has been demonstrated in the retina. METHODS: We performed a spectral-domain optical coherence tomography (OCT) study in patients with PD and healthy controls to measure the peripapillary retinal nerve fiber layer thickness and macular volume. Intra-retinal segmentation was performed to measure the volume of the retinal nerve fiber (RNFL), ganglion cell (GCL), inner plexiform (IPL), inner nuclear (INL), outer plexiform (OPL), and outer nuclear (ONL) layers. Analysis was carried out blinded to the clinical status of study participants. RESULTS: 101 PD and 46 healthy control eyes were included in the study. In PD patients, peripapillary retinal nerve fiber layer was not significantly thinner (96.95 μm vs 94.42 μm, p=0.08) but macular volume was (8.58 mm3 vs 8.33 mm3, p=0.0002). Intra-retinal segmentation showed that PD subjects have reduced GCL, IPL, INL and ONL volumes. In contrast, the OPL volume was significantly increased (0.81 mm3 vs 0.78 mm3 p=0.0214). CONCLUSIONS: Thickening of the OPL is a novel finding which may correspond to the localization of α-synuclein in the OPL of PD patients. We hypothesize that the enlargement of the OPL may represent a potential biomarker of α-synuclein aggregation in PD. This may have significant clinical implications.
BACKGROUND:Parkinson's disease (PD) is a neurodegenerative disorder associated with dopaminergic cell loss and α-synuclein aggregation in Lewy bodies, which has been demonstrated in the retina. METHODS: We performed a spectral-domain optical coherence tomography (OCT) study in patients with PD and healthy controls to measure the peripapillary retinal nerve fiber layer thickness and macular volume. Intra-retinal segmentation was performed to measure the volume of the retinal nerve fiber (RNFL), ganglion cell (GCL), inner plexiform (IPL), inner nuclear (INL), outer plexiform (OPL), and outer nuclear (ONL) layers. Analysis was carried out blinded to the clinical status of study participants. RESULTS: 101 PD and 46 healthy control eyes were included in the study. In PDpatients, peripapillary retinal nerve fiber layer was not significantly thinner (96.95 μm vs 94.42 μm, p=0.08) but macular volume was (8.58 mm3 vs 8.33 mm3, p=0.0002). Intra-retinal segmentation showed that PD subjects have reduced GCL, IPL, INL and ONL volumes. In contrast, the OPL volume was significantly increased (0.81 mm3 vs 0.78 mm3 p=0.0214). CONCLUSIONS: Thickening of the OPL is a novel finding which may correspond to the localization of α-synuclein in the OPL of PDpatients. We hypothesize that the enlargement of the OPL may represent a potential biomarker of α-synuclein aggregation in PD. This may have significant clinical implications.
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