Andrea E Bonny1, Hannah L H Lange2, Erinn M Hade3, Bram Kaufman4, Michael D Reed5, Sam Mesiano6. 1. Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA; The Ohio State University, 410 West 10th Avenue, Columbus, OH 43210, USA. Electronic address: andrea.bonny@nationwidechildrens.org. 2. Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA. 3. The Ohio State University, 410 West 10th Avenue, Columbus, OH 43210, USA. 4. Case Western Reserve University School of Medicine, 2109 Adelbert Road, Cleveland, OH 44106, USA; MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH 44109, USA. 5. Akron Children's Hospital, One Perkins Square, Akron, OH 44308-1062, USA. 6. Case Western Reserve University School of Medicine, 2109 Adelbert Road, Cleveland, OH 44106, USA.
Abstract
OBJECTIVE: To evaluate whether serum adipocytokine concentrations, controlling for baseline adiposity, are predictive of adipose weight gain in adolescents initiating depot medroxyprogesterone acetate (DMPA). METHODS: Percent body fat was measured at baseline and 6 months. Baseline serum adipocytokine concentrations were quantified. RESULTS: Mean percent body fat was 31.6% (±7.6) at baseline and 33.5% (±7.6) at 6 months. In multivariable linear regression modeling (adjusted for baseline percent body fat), Hispanic ethnicity and baseline serum adiponectin concentration were inversely associated (p≤.05) with absolute change in percent body fat at 6 months. CONCLUSIONS: Serum adiponectin concentration may be useful for assessing risk of DMPA-associated adipose gains.
OBJECTIVE: To evaluate whether serum adipocytokine concentrations, controlling for baseline adiposity, are predictive of adipose weight gain in adolescents initiating depot medroxyprogesterone acetate (DMPA). METHODS: Percent body fat was measured at baseline and 6 months. Baseline serum adipocytokine concentrations were quantified. RESULTS: Mean percent body fat was 31.6% (±7.6) at baseline and 33.5% (±7.6) at 6 months. In multivariable linear regression modeling (adjusted for baseline percent body fat), Hispanic ethnicity and baseline serum adiponectin concentration were inversely associated (p≤.05) with absolute change in percent body fat at 6 months. CONCLUSIONS: Serum adiponectin concentration may be useful for assessing risk of DMPA-associated adipose gains.
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