Andrea E Bonny1, Hannah L H Lange2, Lynette K Rogers3, Dave M Gothard4, Michael D Reed5. 1. Nationwide Children's Hospital, Columbus, OH, USA; The Ohio State University, Columbus, OH, USA; The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA. Electronic address: andrea.bonny@nationwidechildrens.org. 2. The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA. 3. The Ohio State University, Columbus, OH, USA; The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA. 4. Biostats Inc., East Canton, OH, USA. 5. Akron Children's Hospital and the Rebecca D. Considine Research Institute, Akron, OH, USA.
Abstract
OBJECTIVE: To explore the relationship between medroxyprogesterone acetate (MPA) pharmacokinetic (PK) parameter estimates and weight gain. STUDY DESIGN: Prospective study of adolescents (N=40; age 12-21 years) initiating DMPA. PK parameters were calculated: maximum MPA concentration (Cmax, ng/mL), time to Cmax (Tmax, days) and elimination rate constant (ng/mL/day). Optimal PK cut points were determined for predicting body mass index (BMI) increase ≥10%. RESULTS: Cmax <2.88 ng/mL and elimination rate constant <0.021 ng/mL/day were associated (p<.05) with BMI increase ≥10%. Elimination rate constant was most predictive of weight gain. CONCLUSIONS: PK evaluation may help identify adolescents at risk of excessive DMPA-associated weight gain.
OBJECTIVE: To explore the relationship between medroxyprogesterone acetate (MPA) pharmacokinetic (PK) parameter estimates and weight gain. STUDY DESIGN: Prospective study of adolescents (N=40; age 12-21 years) initiating DMPA. PK parameters were calculated: maximum MPA concentration (Cmax, ng/mL), time to Cmax (Tmax, days) and elimination rate constant (ng/mL/day). Optimal PK cut points were determined for predicting body mass index (BMI) increase ≥10%. RESULTS: Cmax <2.88 ng/mL and elimination rate constant <0.021 ng/mL/day were associated (p<.05) with BMI increase ≥10%. Elimination rate constant was most predictive of weight gain. CONCLUSIONS: PK evaluation may help identify adolescents at risk of excessive DMPA-associated weight gain.
Authors: Andrea E Bonny; Hannah L H Lange; Erinn M Hade; Bram Kaufman; Michael D Reed; Sam Mesiano Journal: Contraception Date: 2015-06-10 Impact factor: 3.375