| Literature DB >> 26070939 |
Rhys Evans1, Anselm Zdebik1, Coziana Ciurtin2, Stephen B Walsh3.
Abstract
SS is a prevalent and underdiagnosed systemic disease that primarily affects epithelial tissue. It may affect renal function either as epithelial disease causing tubulointerstitial nephritis or as an immune complex-mediated glomerulopathy. These lesions may cause a variety of clinical features, both overt and occult. The epithelial disease is mediated by B and T cells, notably the Th17 subtype. We review the prevalence of renal SS, its presentation, likely pathogenesis and treatment.Entities:
Keywords: B cells; Fanconi syndrome; Sjögren’s syndrome; Th17 cells; autoantibodies; autoimmune epithelialitis; distal renal tubular acidosis; hypocomplementaemia; tubulointerstitial nephritis; vasculitis
Mesh:
Year: 2015 PMID: 26070939 DOI: 10.1093/rheumatology/kev223
Source DB: PubMed Journal: Rheumatology (Oxford) ISSN: 1462-0324 Impact factor: 7.580