| Literature DB >> 26070653 |
Leyla Haghnejad1, Babak Emamalizadeh1, Javad Jamshidi2, Alireza Zare Bidoki3, Hamid Ghaedi1, Ehsan Ahmadi4, Shokoufeh Abdollahi5, Neda Shahmohammadibeni6, Shaghayegh Taghavi1, Atena Fazeli1, Marzieh Motallebi1, Amir Ehtesham Shafiei Zarneh1, Saeed Mohammadihosseinabad7, Mohammad Reza Abbaszadegan8, Shahram Torkamandi1, Masoumeh Amini Gavenaroudi5, Negar Pedram9, Gholam-Ali Shahidi10, Abbas Tafakhori11, Hossein Darvish12, Abolfazl Movafagh13.
Abstract
DNA variations in the fibroblast growth factor 20 gene have been reported to be associated with Parkinson's disease (PD). The rs12720208, a functional SNP located in the 3'UTR region of the gene, was reported as a risk factor for PD. A number of studies, which tried to replicate the result in different populations, failed to detect any associations. In this study, we genotyped rs2720208 SNP in 520 PD patients and 520 healthy controls both from Iran. Significant differences were found in allele and genotype frequencies between patients and controls (p<0.0001 for both). Our results suggest that the rs12720208 polymorphism may be a risk factor for PD in Iranian population.Entities:
Keywords: 3′UTR; FGF20; Iranian population; Parkinson's disease; Polymorphism; miRNA-433
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Year: 2015 PMID： 26070653 DOI： 10.1016/j.jns.2015.05.020
Source DB: PubMed Journal: J Neurol Sci ISSN： 0022-510X Impact factor: 3.181