Faranak Madadi1, Mahmoud Shekari Khaniani2, Ehsan Esmaili Shandiz3, Hormoz Ayromlou4, Safa Najmi4, Babak Emamalizadeh5, Shaghayegh Taghavi5, Javad Jamshidi6, Abbas Tafakhori7, Gholam-Ali Shahidi8, Hossein Darvish5. 1. 1 Neuroscience Research Center, Tabriz University of Medical Sciences , Tabriz, Iran . 2. 2 Department of Medical Genetics, School of Medicine, Tabriz University of Medical Sciences , Tabriz, Iran . 3. 3 Neurology Department, Ganjavian Hospital, Dezful University of Medical Sciences , Dezful, Iran . 4. 4 Department of Neurology, School of Medicine, Tabriz University of Medical Sciences , Tabriz, Iran . 5. 5 Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences , Tehran, Iran . 6. 6 Noncommunicable Diseases Research Center, Fasa University of Medical Sciences , Fasa, Iran . 7. 7 Department of Neurology, School of Medicine, Imam Khomeini Hospital and Iranian Center of Neurological Research, Tehran University of Medical Sciences , Tehran, Iran . 8. 8 Movement Disorders Clinic, Hazrat Rassol Hospital, Iran University of Medical Sciences , Tehran, Iran .
Abstract
AIMS: Parkinson's disease (PD) is one of the most common neurodegenerative disorders; its etiology includes both genetic and environmental factors and their interactions. The ZNF512B, SLC41A1, and ALDH2 genes have recently been identified as contributing to PD. In this study we investigated the association of alleles of these genes with PD in the Iranian population. METHODS: In a case-control study, rs2275294, rs11240569, and rs4767944, three single nucleotide polymorphisms in ZNF512B, SLC41A1, and ALDH2 genes, respectively, were genotyped in 490 PD patients and 490 controls. The genotype and allele frequencies were compared between the two groups using chi-square and logistic regression tests. RESULTS: A significant association between the rs11240569 polymorphism and a reduced risk of PD was found (p = 0.014, OR = 0.76, 95% CI: 0.60-0.94 for allele frequencies). We did not find any associations between PD and the rs2275294 and rs4767944 polymorphisms. CONCLUSION: The association of rs11240569 polymorphism in SLC41A1 gene with reduced risk of PD was replicated in our population.
AIMS: Parkinson's disease (PD) is one of the most common neurodegenerative disorders; its etiology includes both genetic and environmental factors and their interactions. The ZNF512B, SLC41A1, and ALDH2 genes have recently been identified as contributing to PD. In this study we investigated the association of alleles of these genes with PD in the Iranian population. METHODS: In a case-control study, rs2275294, rs11240569, and rs4767944, three single nucleotide polymorphisms in ZNF512B, SLC41A1, and ALDH2 genes, respectively, were genotyped in 490 PDpatients and 490 controls. The genotype and allele frequencies were compared between the two groups using chi-square and logistic regression tests. RESULTS: A significant association between the rs11240569 polymorphism and a reduced risk of PD was found (p = 0.014, OR = 0.76, 95% CI: 0.60-0.94 for allele frequencies). We did not find any associations between PD and the rs2275294 and rs4767944 polymorphisms. CONCLUSION: The association of rs11240569 polymorphism in SLC41A1 gene with reduced risk of PD was replicated in our population.
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Authors: Michal Cibulka; Maria Brodnanova; Marian Grendar; Milan Grofik; Egon Kurca; Ivana Pilchova; Oto Osina; Zuzana Tatarkova; Dusan Dobrota; Martin Kolisek Journal: Int J Mol Sci Date: 2019-09-21 Impact factor: 5.923