Literature DB >> 2607015

Serial ultrastructural studies of scrapie in hamsters.

P P Liberski1, D M Asher, R Yanagihara, C J Gibbs, D C Gajdusek.   

Abstract

We report sequential studies of the ultrastructural neuropathology of the subcortical grey matter of hamsters infected with the 263K strain of scrapie virus. Vacuolation in this model develops relatively late in the incubation period, while tubulovesicular structures appear early. Furthermore, neuroaxonal dystrophy, accumulations of branching tubules, and neuronal change consisting of intracytoplasmic "whorls" of proliferating membranes constitute prominent features of scrapie-related neurodegeneration.

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Year:  1989        PMID： 2607015     DOI： 10.1016/0021-9975(89)90026-1

Source DB:  PubMed          Journal:  J Comp Pathol        ISSN： 0021-9975            Impact factor:   1.311


  8 in total

1.  Molecular changes of preclinical scrapie can be detected by infrared spectroscopy.

Authors:  Janina Kneipp; Michael Beekes; Peter Lasch; Dieter Naumann
Journal:  J Neurosci       Date:  2002-04-15       Impact factor: 6.167

2.  Scrapie inoculation of mice: light and electron microscopy of the superior colliculi.

Authors:  M Jeffrey; J R Scott; H Fraser
Journal:  Acta Neuropathol       Date:  1991       Impact factor: 17.088

3.  Neuronal autophagic vacuoles in experimental scrapie and Creutzfeldt-Jakob disease.

Authors:  P P Liberski; R Yanagihara; C J Gibbs; D C Gajdusek
Journal:  Acta Neuropathol       Date:  1992       Impact factor: 17.088

4.  Cytopathological changes in human and animals brains in prion diseases.

Authors:  V Ya Karmysheva; V V Pogodina; V M Roikhel
Journal:  Neurosci Behav Physiol       Date:  2004-06

5.  Tubulovesicular structures in human and experimental Creutzfeldt-Jakob disease.

Authors:  P P Liberski; H Budka; E Sluga; M Barcikowska; H Kwiecinski
Journal:  Eur J Epidemiol       Date:  1991-09       Impact factor: 8.082

6.  Mechanism of the damage to myelinated axons in experimental Creutzfeldt-Jakob disease in mice: an ultrastructural study.

Authors:  P P Liberski; R Yanagihara; C J Gibbs; D C Gajdusek
Journal:  Eur J Epidemiol       Date:  1991-09       Impact factor: 8.082

7.  Heightened expression of tumor necrosis factor alpha, interleukin 1 alpha, and glial fibrillary acidic protein in experimental Creutzfeldt-Jakob disease in mice.

Authors:  R Kordek; V R Nerurkar; P P Liberski; S Isaacson; R Yanagihara; D C Gajdusek
Journal:  Proc Natl Acad Sci U S A       Date:  1996-09-03       Impact factor: 11.205

8.  Tubulovesicular structures in Creutzfeldt-Jakob disease.

Authors:  P P Liberski; H Budka; E Sluga; M Barcikowska; H Kwiecinski
Journal:  Acta Neuropathol       Date:  1992       Impact factor: 17.088
  8 in total

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