Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Neuronal autophagic vacuoles in experimental scrapie and Creutzfeldt-Jakob disease.

Literature DB >> 1557945

Neuronal autophagic vacuoles in experimental scrapie and Creutzfeldt-Jakob disease.

P P Liberski¹, R Yanagihara, C J Gibbs, D C Gajdusek.

Abstract

We report the presence of autophagic vacuoles (AV) in neuronal perikarya and neuronal processes of rodents with experimental scrapie and Creutzfeldt-Jakob disease. AV were composed of sequestrated cytoplasmic areas containing ribosomes and occasionally mitochondria and small secondary vacuoles. The formation of AV may contribute to neuronal degeneration and ultimately to neuronal loss.

Entities: Disease

Mesh：

Year: 1992 PMID： 1557945 DOI： 10.1007/bf00308472

Source DB: PubMed Journal: Acta Neuropathol ISSN： 0001-6322 Impact factor: 17.088

19 in total

1. DEGENERATION OF THE CEREBELLAR AND HYPOTHALAMONEUROHYPOPHYSIAL SYSTEMS IN SHEEP WITH SCRAPIE; AND ITS RELATIONSHIP TO HUMAN SYSTEM DEGENERATIONS.

Authors: E BECK; P M DANIEL; H B PARRY
Journal: Brain Date: 1964-03 Impact factor: 13.501

2. Significance of vacuolated neurones in the medulla of sheep affected with scrapie.

Authors: I ZLOTNIK
Journal: Nature Date: 1957-08-24 Impact factor: 49.962

3. Evidence that the transmission of one source of scrapie agent to hamsters involves separation of agent strains from a mixture.

Authors: R H Kimberlin; C A Walker
Journal: J Gen Virol Date: 1978-06 Impact factor: 3.891

4. Serial ultrastructural studies of scrapie in hamsters.

Authors: P P Liberski; D M Asher; R Yanagihara; C J Gibbs; D C Gajdusek
Journal: J Comp Pathol Date: 1989-11 Impact factor: 1.311

5. Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques.

Authors: M Scott; D Foster; C Mirenda; D Serban; F Coufal; M Wälchli; M Torchia; D Groth; G Carlson; S J DeArmond; D Westaway; S B Prusiner
Journal: Cell Date: 1989-12-01 Impact factor: 41.582

6. Electron microscopic observations on dystrophic neurites in hamster brains infected with the 263K strain of scrapie.

Authors: P P Liberski
Journal: J Comp Pathol Date: 1987-01 Impact factor: 1.311

7. Altered plasma membranes in experimental scrapie.

Authors: P Lampert; J Hooks; C J Gibbs; D C Gajdusek
Journal: Acta Neuropathol Date: 1971 Impact factor: 17.088

8. Characteristics of a short incubation model of scrapie in the golden hamster.

Authors: R H Kimberlin; C Walker
Journal: J Gen Virol Date: 1977-02 Impact factor: 3.891

9. Transmission of chronic spongiform encephalopathy with kuru plaques from humans to small rodents.

Authors: J Tateishi; M Ohta; M Koga; Y Sato; Y Kuroiwa
Journal: Ann Neurol Date: 1979-06 Impact factor: 10.422

10. Evidence for an unconventional virus in mouse-adapted Creutzfeldt-Jakob disease.

Authors: D T Kingsbury; D A Smeltzer; H L Amyx; C J Gibbs; D C Gajdusek
Journal: Infect Immun Date: 1982-09 Impact factor: 3.441

7 in total

1. Tryptamine induces tryptophanyl-tRNA synthetase-mediated neurodegeneration with neurofibrillary tangles in human cell and mouse models.

Authors: Elena L Paley; Galina Denisova; Olga Sokolova; Natalia Posternak; Xukui Wang; Anna-Liisa Brownell
Journal: Neuromolecular Med Date: 2007 Impact factor: 3.843

2. Neuronal death induced by misfolded prion protein is due to NAD+ depletion and can be relieved in vitro and in vivo by NAD+ replenishment.

Authors: Minghai Zhou; Gregory Ottenberg; Gian Franco Sferrazza; Christopher Hubbs; Mohammad Fallahi; Gavin Rumbaugh; Alicia F Brantley; Corinne I Lasmézas
Journal: Brain Date: 2015-02-11 Impact factor: 13.501