Literature DB >> 26068024

Minimally-invasive Technique for Injection into Rat Optic Nerve.

Kateryna Raykova1, Melina V Jones1, Hwa Huang1, Paul F Hoffman1, Michael Levy2.   

Abstract

The rat optic nerve is a useful model for stem cell regeneration research. Direct injection into the rat optic nerve allows delivery into the central nervous system in a minimally-invasive surgery without bone removal. This technique describes an approach to visualization and direct injection of the optic nerve following minor fascial dissection from the orbital ridge, using a conjunctival traction suture to gently pull the eye down and out. Representative examples of an injected optic nerve show successful injection of dyed beads.

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Mesh：

Year:  2015        PMID： 26068024      PMCID： PMC4542817          DOI： 10.3791/52249

Source DB:  PubMed          Journal:  J Vis Exp        ISSN： 1940-087X            Impact factor:   1.355


  9 in total

Review 1.  Minimally invasive approaches to the cervical spine.

Authors:  Paul C Celestre; Pablo R Pazmiño; Mark M Mikhael; Christopher F Wolf; Lacey A Feldman; Carl Lauryssen; Jeffrey C Wang
Journal:  Orthop Clin North Am       Date:  2011-10-13       Impact factor: 2.472

2.  Quantitative study of the development of the optic nerve in rats reared in the dark during early postnatal life.

Authors:  Y Fukui; S Hayasaka; K S Bedi; H S Ozaki; Y Takeuchi
Journal:  J Anat       Date:  1991-02       Impact factor: 2.610

Review 3.  Current approaches and future prospects for stem cell rescue and regeneration of the retina and optic nerve.

Authors:  Annegret Dahlmann-Noor; Sauparnika Vijay; Hari Jayaram; Astrid Limb; Peng Tee Khaw
Journal:  Can J Ophthalmol       Date:  2010-08       Impact factor: 1.882

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Authors:  H A Quigley; D S Iglesia
Journal:  Eye (Lond)       Date:  2004-11       Impact factor: 3.775

Review 5.  Regenerative nanomedicine for vision restoration.

Authors:  Marco A Zarbin; Timothy Arlow; Robert Ritch
Journal:  Mayo Clin Proc       Date:  2013-12       Impact factor: 7.616

6.  [Optic neuritis--from diagnosis to optic nerve transplantation].

Authors:  E Adachi-Usami
Journal:  Nippon Ganka Gakkai Zasshi       Date:  2000-12

Review 7.  Gene therapy and transplantation in the retinofugal pathway.

Authors:  Alan R Harvey; Mats Hellström; Jenny Rodger
Journal:  Prog Brain Res       Date:  2009       Impact factor: 2.453

Review 8.  Optic nerve disease and axon pathophysiology.

Authors:  Alireza Ghaffarieh; Leonard A Levin
Journal:  Int Rev Neurobiol       Date:  2012       Impact factor: 3.230

9.  Optic nerve inflammation and demyelination in a rodent model of nonarteritic anterior ischemic optic neuropathy.

Authors:  Bernard J Slater; Fernandino L Vilson; Yan Guo; Daniel Weinreich; Shelly Hwang; Steven L Bernstein
Journal:  Invest Ophthalmol Vis Sci       Date:  2013-12-05       Impact factor: 4.799
  9 in total

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