Kamran Heidari1, Ali Vafaee1, Alireza Maleki Rastekenari2, Mehrdad Taghizadeh1, Ensieh Ghaffari Shad3, Rob Eley4,5, Michael Sinnott4, Shadi Asadollahi6. 1. a Department of Emergency Medicine , Loghmane-Hakim Hospital, Shahid Beheshti University of Medical Sciences , Tehran , Iran. 2. b School of Medicine, Babol University of Medical Sciences , Babol , Mazandaran , Iran. 3. c School of Medicine, Alborz University of Medical Sciences , Karaj , Tehran , Iran. 4. d Department of Emergency Medicine , Princess Alexandra Hospital , Queensland , Australia. 5. e School of Medicine, The University of Queensland , Brisbane , Australia , and. 6. f School of Medicine, Shahid Beheshti University of Medical Sciences , Tehran , Iran.
Abstract
PRIMARY OBJECTIVE: To determine whether S100B protein in serum can predict intracranial lesions on computed tomography (CT) scan after mild traumatic brain injury (MTBI). RESEARCH DESIGN: Systematic review and meta-analysis Methods and procedures: A literature search was conducted using Medline, Embase, Cochrane, Google Scholar, CINAHL, SUMSearch, Bandolier, Trip databases, bibliographies from identified articles and review article references. Eligible articles were defined as observational studies including patients with MTBI who underwent post-traumatic head CT scan and assessing the screening role of S100B protein. MAIN OUTCOMES AND RESULTS: There was a significant positive association between S100B protein concentration and positive CT scan (22 studies, SMD = 1.92, 95% CI = 1.29-2.45, I2 = 100%; p < 0.001). The pooled sensitivity and specificity values for a cut-point range = 0.16-0.20 µg L-1 were 98.65 (95% CI = 95.53-101.77; I2 = 0.0%) and 50.69 (95% CI = 40.69-60.69; I2 = 76.3%), respectively. The threshold for serum S100B protein with 99.63 (95% CI = 96.00-103.25; I2 = 0.0%) sensitivity and 46.94 (95% CI = 39.01-54.87; I2 = 95.5%) specificity was > 0.20 µg L-1. CONCLUSIONS: After MTBI, serum S100B protein levels are significantly associated with the presence of intracranial lesions on CT scan. Measuring the protein could be useful in screening high risk MTBI patients and decreasing unnecessary CT examinations.
PRIMARY OBJECTIVE: To determine whether S100B protein in serum can predict intracranial lesions on computed tomography (CT) scan after mild traumatic brain injury (MTBI). RESEARCH DESIGN: Systematic review and meta-analysis Methods and procedures: A literature search was conducted using Medline, Embase, Cochrane, Google Scholar, CINAHL, SUMSearch, Bandolier, Trip databases, bibliographies from identified articles and review article references. Eligible articles were defined as observational studies including patients with MTBI who underwent post-traumatic head CT scan and assessing the screening role of S100B protein. MAIN OUTCOMES AND RESULTS: There was a significant positive association between S100B protein concentration and positive CT scan (22 studies, SMD = 1.92, 95% CI = 1.29-2.45, I2 = 100%; p < 0.001). The pooled sensitivity and specificity values for a cut-point range = 0.16-0.20 µg L-1 were 98.65 (95% CI = 95.53-101.77; I2 = 0.0%) and 50.69 (95% CI = 40.69-60.69; I2 = 76.3%), respectively. The threshold for serum S100B protein with 99.63 (95% CI = 96.00-103.25; I2 = 0.0%) sensitivity and 46.94 (95% CI = 39.01-54.87; I2 = 95.5%) specificity was > 0.20 µg L-1. CONCLUSIONS: After MTBI, serum S100B protein levels are significantly associated with the presence of intracranial lesions on CT scan. Measuring the protein could be useful in screening high risk MTBI patients and decreasing unnecessary CT examinations.
Authors: Alicia K Au; Michael J Bell; Ericka L Fink; Rajesh K Aneja; Patrick M Kochanek; Robert S B Clark Journal: Neurocrit Care Date: 2018-02 Impact factor: 3.210
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Authors: Linnéa Lagerstedt; Juan José Egea-Guerrero; Alejandro Bustamante; Joan Montaner; Ana Rodríguez-Rodríguez; Amir El Rahal; Natacha Turck; Manuel Quintana; Roser García-Armengol; Carmen Melinda Prica; Elisabeth Andereggen; Lara Rinaldi; Asita Sarrafzadeh; Karl Schaller; Jean-Charles Sanchez Journal: PLoS One Date: 2017-04-18 Impact factor: 3.240