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Literature DB >> 27374986

WONOEP appraisal: Molecular and cellular biomarkers for epilepsy.

Lauren E Walker¹, Damir Janigro², Uwe Heinemann³, Raili Riikonen⁴, Christophe Bernard⁵, Manisha Patel⁶.

Abstract

Peripheral biomarkers have myriad potential uses for treatment, prediction, prognostication, and pharmacovigilance in epilepsy. To date, no single peripheral biomarker has demonstrated proven effectiveness, although multiple candidates are in development. In this review, we discuss the major areas of focus including inflammation, blood-brain barrier dysfunction, redox alterations, metabolism, hormones and growth factors. Wiley Periodicals, Inc.

Entities: Chemical Disease Gene Mutation Species

Keywords: Blood-brain barrier; High mobility group box 1 (HMGB1); Inflammation; Insulin-like growth factor; S100B; brain derived neurotrophic factor

Mesh：

Substances：

Year: 2016 PMID： 27374986 PMCID： PMC5515385 DOI： 10.1111/epi.13460

Source DB: PubMed Journal: Epilepsia ISSN： 0013-9580 Impact factor: 5.864

76 in total

Review 1. Biomarkers and surrogate endpoints: preferred definitions and conceptual framework.

Authors:
Journal: Clin Pharmacol Ther Date: 2001-03 Impact factor: 6.875

2. Cliniconeuropathologic correlations show astroglial albumin storage as a common factor in epileptogenic vascular lesions.

Authors: Anna Raabe; Ann Kristin Schmitz; Katharina Pernhorst; Alexander Grote; Christian von der Brelie; Horst Urbach; Alon Friedman; Albert J Becker; Christian E Elger; Pitt Niehusmann
Journal: Epilepsia Date: 2012-03 Impact factor: 5.864

Review 3. Modulation of glucocorticoid metabolism by the growth hormone - IGF-1 axis.

Authors: Amar Agha; John P Monson
Journal: Clin Endocrinol (Oxf) Date: 2007-04 Impact factor: 3.478

4. Reactive oxygen species initiate a metabolic collapse in hippocampal slices: potential trigger of cortical spreading depression.

Authors: Anton Malkov; Anton I Ivanov; Irina Popova; Marat Mukhtarov; Olena Gubkina; Tatsiana Waseem; Piotr Bregestovski; Yuri Zilberter
Journal: J Cereb Blood Flow Metab Date: 2014-07-16 Impact factor: 6.200

5. Redox modification of cysteine residues regulates the cytokine activity of high mobility group box-1 (HMGB1).

Authors: Huan Yang; Peter Lundbäck; Lars Ottosson; Helena Erlandsson-Harris; Emilie Venereau; Marco E Bianchi; Yousef Al-Abed; Ulf Andersson; Kevin J Tracey; Daniel J Antoine
Journal: Mol Med Date: 2012-03-30 Impact factor: 6.354

6. Activation of Toll-like receptor, RAGE and HMGB1 signalling in malformations of cortical development.

Authors: Emanuele Zurolo; Anand Iyer; Mattia Maroso; Caterina Carbonell; Jasper J Anink; Teresa Ravizza; Kees Fluiter; Wim G M Spliet; Peter C van Rijen; Annamaria Vezzani; Eleonora Aronica
Journal: Brain Date: 2011-03-16 Impact factor: 13.501

7. Serum S-100beta as a possible marker of blood-brain barrier disruption.

Authors: M Kapural; Lj Krizanac-Bengez; G Barnett; J Perl; T Masaryk; D Apollo; P Rasmussen; M R Mayberg; D Janigro
Journal: Brain Res Date: 2002-06-14 Impact factor: 3.252

Review 8. Serum ubiquitin C-terminal hydrolase L1 as a biomarker for traumatic brain injury: a systematic review and meta-analysis.

Authors: Jian Li; Chao Yu; Yang Sun; Yuyuan Li
Journal: Am J Emerg Med Date: 2015-05-29 Impact factor: 2.469

Review 9. Inflammatory events at blood-brain barrier in neuroinflammatory and neurodegenerative disorders: implications for clinical disease.

Authors: Helga E de Vries; Gijs Kooij; Dan Frenkel; Spiros Georgopoulos; Alon Monsonego; Damir Janigro
Journal: Epilepsia Date: 2012-11 Impact factor: 5.864

10. Changes in cerebrospinal fluid biomarkers in human herpesvirus-6-associated acute encephalopathy/febrile seizures.

Authors: Naoyuki Tanuma; Rie Miyata; Keisuke Nakajima; Akihisa Okumura; Masaya Kubota; Shin-ichiro Hamano; Masaharu Hayashi
Journal: Mediators Inflamm Date: 2014-09-11 Impact factor: 4.711

14 in total

1. Development of a biomarker database toward performing disease classification and finding disease interrelations.

Authors: Shaikh Farhad Hossain; Ming Huang; Naoaki Ono; Aki Morita; Shigehiko Kanaya; Md Altaf-Ul-Amin
Journal: Database (Oxford) Date: 2021-03-11 Impact factor: 3.451

Review 2. Review: The past, present and future challenges in epilepsy-related and sudden deaths and biobanking.

Authors: M Thom; M Boldrini; E Bundock; M N Sheppard; O Devinsky
Journal: Neuropathol Appl Neurobiol Date: 2018-02 Impact factor: 8.090

Review 3. Breaking Bad: the Structure and Function of the Blood-Brain Barrier in Epilepsy.

Authors: Hadas Han; Aniv Mann; Dana Ekstein; Sara Eyal
Journal: AAPS J Date: 2017-05-26 Impact factor: 4.009

4. LiqBioer: a manually curated database of cancer biomarkers in body fluid.

Authors: Yiding Geng; Lu Jin; Guangjue Tang; Zhangxiang Zhao; Yunyan Gu; Dan Yang
Journal: Database (Oxford) Date: 2022-09-02 Impact factor: 4.462

5. Identification of Serum Biomarkers for Differentiating Epileptic Seizures from Psychogenic Attacks Using a Proteomic Approach; a Comparative study.

Authors: Mohsen Parvareshi Hamrah; Mostafa Rezaei Tavirani; Monireh Movahedi; Sanaz Ahmadi Karvigh
Journal: Arch Acad Emerg Med Date: 2020-10-29

Review 6. Innate and adaptive immunity in human epilepsies.

Authors: Jan Bauer; Albert J Becker; Wassim Elyaman; Jukka Peltola; Stephan Rüegg; Maarten J Titulaer; James A Varley; Ettore Beghi
Journal: Epilepsia Date: 2017-07 Impact factor: 5.864

7. Blood-Brain Barrier Leakage during Early Epileptogenesis Is Associated with Rapid Remodeling of the Neurovascular Unit.

Authors: Marion Bankstahl; Heike Breuer; Ina Leiter; Martin Märkel; Pablo Bascuñana; Dominik Michalski; Frank M Bengel; Wolfgang Löscher; Martin Meier; Jens P Bankstahl; Wolfgang Härtig
Journal: eNeuro Date: 2018-05-30