OBJECTIVES: We estimated HCV incidence among individuals who repeatedly underwent anti-HCV testing. METHODS: We studied HCV-negative individuals who had at least 2 tests between April 1992 and September 2012 in British Columbia, Canada. We calculated incidence as the number of new infections per 100 person-years at risk. RESULTS: From 1992 to 2012, 323 598 individuals who persistently tested negative and 7490 HCV seroconverters contributed 1 774 262 person-years of observation time. Incidence rates ranged from 2.66 infections per 100 person-years (95% confidence interval [CI] = 2.07, 3.35) in 1993 to 0.25 infections per 100 person-years (95% CI = 0.21, 0.29) in 2011. Rates declined sharply in the 1990s and declined more gradually in the 2000s. Incidence declined with age; highest incidence rates were among those aged 15 to 24 years. Incidence among male repeat testers exceeded that of female repeat testers across all years, although the gap narrowed over time. CONCLUSIONS: Addictions treatment, harm reduction, prevention education, and novel initiatives to remove barriers in health infrastructure need to be intensified for those who inject drugs, particularly men and younger persons.
OBJECTIVES: We estimated HCV incidence among individuals who repeatedly underwent anti-HCV testing. METHODS: We studied HCV-negative individuals who had at least 2 tests between April 1992 and September 2012 in British Columbia, Canada. We calculated incidence as the number of new infections per 100 person-years at risk. RESULTS: From 1992 to 2012, 323 598 individuals who persistently tested negative and 7490 HCV seroconverters contributed 1 774 262 person-years of observation time. Incidence rates ranged from 2.66 infections per 100 person-years (95% confidence interval [CI] = 2.07, 3.35) in 1993 to 0.25 infections per 100 person-years (95% CI = 0.21, 0.29) in 2011. Rates declined sharply in the 1990s and declined more gradually in the 2000s. Incidence declined with age; highest incidence rates were among those aged 15 to 24 years. Incidence among male repeat testers exceeded that of female repeat testers across all years, although the gap narrowed over time. CONCLUSIONS: Addictions treatment, harm reduction, prevention education, and novel initiatives to remove barriers in health infrastructure need to be intensified for those who inject drugs, particularly men and younger persons.
Authors: Susan E Fernyak; Kimberly Page-Shafer; Timothy A Kellogg; William McFarland; Mitchell H Katz Journal: J Acquir Immune Defic Syndr Date: 2002-09-01 Impact factor: 3.731
Authors: Paul K Nelson; Bradley M Mathers; Benjamin Cowie; Holly Hagan; Don Des Jarlais; Danielle Horyniak; Louisa Degenhardt Journal: Lancet Date: 2011-07-27 Impact factor: 79.321
Authors: Bryce D Smith; Geoff A Beckett; Anthony Yartel; Deborah Holtzman; Nita Patel; John W Ward Journal: Am J Public Health Date: 2014-01-16 Impact factor: 9.308
Authors: Margot Kuo; Deborah M Money; Maria Alvarez; Jane A Buxton; Mel Krajden; Richard T Lester; Gina Ogilvie; Mark Gilbert Journal: J Obstet Gynaecol Can Date: 2014-06
Authors: Anneke S de Vos; Jannie J van der Helm; Amy Matser; Maria Prins; Mirjam E E Kretzschmar Journal: Addiction Date: 2013-03-13 Impact factor: 6.526
Authors: Jannie J van der Helm; Maria Prins; Julia del Amo; Heiner C Bucher; Geneviève Chêne; Maria Dorrucci; John Gill; Osamah Hamouda; Mette Sannes; Kholoud Porter; Ronald B Geskus Journal: AIDS Date: 2011-05-15 Impact factor: 4.177
Authors: Zahid Ahmad Butt; Nabin Shrestha; Stanley Wong; Margot Kuo; Dionne Gesink; Mark Gilbert; Jason Wong; Amanda Yu; Maria Alvarez; Hasina Samji; Jane A Buxton; James C Johnston; Victoria J Cook; David Roth; Theodora Consolacion; Michelle Murti; Travis S Hottes; Gina Ogilvie; Robert Balshaw; Mark W Tyndall; Mel Krajden; Naveed Z Janjua Journal: PLoS One Date: 2017-08-22 Impact factor: 3.240
Authors: James Wilton; Stanley Wong; Roy Purssell; Younathan Abdia; Mei Chong; Mohammad Ehsanul Karim; Aaron MacInnes; Sofia R Bartlett; Rob F Balshaw; Tara Gomes; Amanda Yu; Maria Alvarez; Richard C Dart; Mel Krajden; Jane A Buxton; Naveed Z Janjua Journal: JAMA Netw Open Date: 2022-01-04
Authors: Nasheed Moqueet; Ramandip Grewal; Tony Mazzulli; Curtis Cooper; Sandra L Gardner; Irving E Salit; Abigail Kroch; Ann N Burchell Journal: Health Sci Rep Date: 2021-09-18