Margot Kuo1, Deborah M Money2, Maria Alvarez1, Jane A Buxton3, Mel Krajden4, Richard T Lester5, Gina Ogilvie6, Mark Gilbert3. 1. British Columbia Centre for Disease Control, Vancouver BC. 2. Department of Obstetrics and Gynaecology, University of British Columbia BC Women's Hospital, Vancouver BC; Women's Health Research Institute, Vancouver BC. 3. British Columbia Centre for Disease Control, Vancouver BC; School of Population and Public Health, University of British Columbia, Vancouver BC. 4. British Columbia Centre for Disease Control, Vancouver BC; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver BC. 5. British Columbia Centre for Disease Control, Vancouver BC; Department of Medicine, Division of Infectious Diseases, University of British Columbia, Vancouver BC. 6. British Columbia Centre for Disease Control, Vancouver BC; Faculty of Medicine, University of British Columbia, Vancouver BC.
Abstract
OBJECTIVE: Test uptake and case detection trends for rubella, syphilis, HIV, and hepatitis C (HCV) were compared among the 2007 to 2011 cohort of women undergoing prenatal testing in British Columbia. Analysis involved linkage of provincially centralized laboratory and surveillance data to assess prenatal test uptake and rates of newly diagnosed versus prevalent infections. METHODS: We included prenatal specimens submitted from BC women aged 16 to 45 years in 2007 to 2011. Laboratory records were linked to provincial surveillance systems to identify confirmed maternal syphilis and HIV cases. Previous positive status was determined for HIV and HCV if a prior confirmed case was identified from laboratory records. We determined rates of HIV and HCV newly identified at prenatal screening (new diagnoses per 100 000 per year). Prevalence for HIV and HCV was the sum of all new and prior diagnoses (prevalence per 100 000 per year). RESULTS: Of 233 203 women, 96.9% were screened for rubella, 93.3% for syphilis, 93.8% for HIV, and 21.5% for HCV. From 2007 to 2011, the overall rates of new diagnoses were 15.4, 5.1, and 82.8 cases per 100 000 per year for syphilis, HIV, and HCV, respectively. The overall prevalence was 45.9 and 551.5 cases per 100 000 per year for HIV and HCV, respectively (0.05% and 0.6%). From 2007 to 2011, new diagnoses of HCV decreased 40% from 106.0 to 62.1 cases per 100 000 per year. HCV prevalence did not change and increased with maternal age. CONCLUSION: This study links surveillance and laboratory data to provide a provincial picture of prenatal screening test uptake and case detection, with the advantage of distinguishing new from prior diagnoses. This information can help guide prenatal communicable disease screening policy.
OBJECTIVE: Test uptake and case detection trends for rubella, syphilis, HIV, and hepatitis C (HCV) were compared among the 2007 to 2011 cohort of women undergoing prenatal testing in British Columbia. Analysis involved linkage of provincially centralized laboratory and surveillance data to assess prenatal test uptake and rates of newly diagnosed versus prevalent infections. METHODS: We included prenatal specimens submitted from BC women aged 16 to 45 years in 2007 to 2011. Laboratory records were linked to provincial surveillance systems to identify confirmed maternal syphilis and HIV cases. Previous positive status was determined for HIV and HCV if a prior confirmed case was identified from laboratory records. We determined rates of HIV and HCV newly identified at prenatal screening (new diagnoses per 100 000 per year). Prevalence for HIV and HCV was the sum of all new and prior diagnoses (prevalence per 100 000 per year). RESULTS: Of 233 203 women, 96.9% were screened for rubella, 93.3% for syphilis, 93.8% for HIV, and 21.5% for HCV. From 2007 to 2011, the overall rates of new diagnoses were 15.4, 5.1, and 82.8 cases per 100 000 per year for syphilis, HIV, and HCV, respectively. The overall prevalence was 45.9 and 551.5 cases per 100 000 per year for HIV and HCV, respectively (0.05% and 0.6%). From 2007 to 2011, new diagnoses of HCV decreased 40% from 106.0 to 62.1 cases per 100 000 per year. HCV prevalence did not change and increased with maternal age. CONCLUSION: This study links surveillance and laboratory data to provide a provincial picture of prenatal screening test uptake and case detection, with the advantage of distinguishing new from prior diagnoses. This information can help guide prenatal communicable disease screening policy.
Authors: Margot Kuo; Naveed Z Janjua; Ann N Burchell; Jane A Buxton; Mel Krajden; Mark Gilbert Journal: Am J Public Health Date: 2015-06-11 Impact factor: 9.308
Authors: Sabrina S Plitt; Trenton R Smith; Warren Berry; Mariam Osman; Ambikaipakan Senthilselvan; Carmen L Charlton Journal: Can J Public Health Date: 2020-02-03
Authors: Luciane Rodrigues Pedreira de Cerqueira; Denise L M Monteiro; Stella R Taquette; Nádia C P Rodrigues; Alexandre J B Trajano; Flavio Monteiro de Souza; Bianca De Melo Araújo Journal: Rev Inst Med Trop Sao Paulo Date: 2017-12-21 Impact factor: 1.846