B Cesar1, M G Dwyer2, J L Shucard3, P Polak4, N Bergsland5, R H B Benedict6, B Weinstock-Guttman6, D W Shucard3, R Zivadinov7. 1. From the Buffalo Neuroimaging Analysis Center, Department of Neurology (B.C., M.G.D., P.P., N.B., R.Z.) Division of Cognitive and Behavioral Neurosciences (B.C., J.L.S., D.W.S.). 2. From the Buffalo Neuroimaging Analysis Center, Department of Neurology (B.C., M.G.D., P.P., N.B., R.Z.) Department of Neurology (M.G.D., J.L.S., R.H.B.B., B.W.-G., D.W.S.). 3. Department of Neurology (M.G.D., J.L.S., R.H.B.B., B.W.-G., D.W.S.) Division of Cognitive and Behavioral Neurosciences (B.C., J.L.S., D.W.S.) Neuroscience Program (J.L.S., D.W.S.). 4. From the Buffalo Neuroimaging Analysis Center, Department of Neurology (B.C., M.G.D., P.P., N.B., R.Z.). 5. From the Buffalo Neuroimaging Analysis Center, Department of Neurology (B.C., M.G.D., P.P., N.B., R.Z.) Magnetic Resonance Laboratory (N.B.), IRCCS Don Gnocchi Foundation, Milan, Italy. 6. Department of Neurology (M.G.D., J.L.S., R.H.B.B., B.W.-G., D.W.S.). 7. From the Buffalo Neuroimaging Analysis Center, Department of Neurology (B.C., M.G.D., P.P., N.B., R.Z.) MRI Clinical Translational Research Center (R.Z.), School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York rzivadinov@bnac.net.
Abstract
BACKGROUND AND PURPOSE: Multiple sclerosis and neuropsychiatric systemic lupus erythematosus are autoimmune diseases with similar CNS inflammatory and neurodegenerative characteristics. Our aim was to investigate white matter tract changes and their association with cognitive function in patients with MS and those with neuropsychiatric systemic lupus erythematosus compared with healthy controls by using diffusion tensor imaging. MATERIALS AND METHODS: Thirty patients with relapsing-remitting MS and 23 patients with neuropsychiatric systemic lupus erythematosus matched for disease severity and duration and 43 healthy controls were scanned with 3T MR imaging. The DTI was postprocessed, corrected for lesions, and analyzed with tract-based spatial statistics. Cognitive assessment included examination of processing speed; visual, auditory/verbal, and visual-spatial memory; and sustained attention and executive function. Differences were considered significant at P < .05. RESULTS: Tract-based spatial statistics analysis revealed significantly decreased fractional anisotropy and increased mean diffusivity in patients with MS compared with healthy controls, decreased fractional anisotropy in patients with MS compared with those with neuropsychiatric systemic lupus erythematosus, and an increased mean diffusivity in patients with neuropsychiatric systemic lupus erythematosus compared with healthy controls. Patients with MS showed decreased fractional anisotropy throughout central WM pathways, including the corpus callosum and the inferior longitudinal and fronto-occipital fasciculi compared with those with neuropsychiatric systemic lupus erythematosus. Altered cognitive scores in patients with MS were significantly associated with decreased fractional anisotropy and increased mean diffusivity in all examined domains, while in patients with diffuse neuropsychiatric systemic lupus erythematosus, only decreased fractional anisotropy in the superior WM pathways showed significant association with executive function. CONCLUSIONS: Patients with MS and neuropsychiatric systemic lupus erythematosus showed widespread WM tract alterations outside overt lesions, though more severe changes were identified in patients with MS. The WM tract changes were associated with cognitive dysfunction in all explored domains only in patients with MS.
BACKGROUND AND PURPOSE:Multiple sclerosis and neuropsychiatric systemic lupus erythematosus are autoimmune diseases with similar CNS inflammatory and neurodegenerative characteristics. Our aim was to investigate white matter tract changes and their association with cognitive function in patients with MS and those with neuropsychiatric systemic lupus erythematosus compared with healthy controls by using diffusion tensor imaging. MATERIALS AND METHODS: Thirty patients with relapsing-remitting MS and 23 patients with neuropsychiatric systemic lupus erythematosus matched for disease severity and duration and 43 healthy controls were scanned with 3T MR imaging. The DTI was postprocessed, corrected for lesions, and analyzed with tract-based spatial statistics. Cognitive assessment included examination of processing speed; visual, auditory/verbal, and visual-spatial memory; and sustained attention and executive function. Differences were considered significant at P < .05. RESULTS: Tract-based spatial statistics analysis revealed significantly decreased fractional anisotropy and increased mean diffusivity in patients with MS compared with healthy controls, decreased fractional anisotropy in patients with MS compared with those with neuropsychiatric systemic lupus erythematosus, and an increased mean diffusivity in patients with neuropsychiatric systemic lupus erythematosus compared with healthy controls. Patients with MS showed decreased fractional anisotropy throughout central WM pathways, including the corpus callosum and the inferior longitudinal and fronto-occipital fasciculi compared with those with neuropsychiatric systemic lupus erythematosus. Altered cognitive scores in patients with MS were significantly associated with decreased fractional anisotropy and increased mean diffusivity in all examined domains, while in patients with diffuse neuropsychiatric systemic lupus erythematosus, only decreased fractional anisotropy in the superior WM pathways showed significant association with executive function. CONCLUSIONS:Patients with MS and neuropsychiatric systemic lupus erythematosus showed widespread WM tract alterations outside overt lesions, though more severe changes were identified in patients with MS. The WM tract changes were associated with cognitive dysfunction in all explored domains only in patients with MS.
Authors: Hui Jing Yu; Christopher Christodoulou; Vikram Bhise; Daniel Greenblatt; Yashma Patel; Dana Serafin; Mirjana Maletic-Savatic; Lauren B Krupp; Mark E Wagshul Journal: Neuroimage Date: 2011-10-29 Impact factor: 6.556
Authors: M Hughes; P C Sundgren; X Fan; B Foerster; B Nan; R C Welsh; J A Williamson; J Attwood; P V Maly; T L Chenevert; W McCune; S Gebarski Journal: Acta Radiol Date: 2007-03 Impact factor: 1.990
Authors: Essam A Abda; Zahraa I Selim; Moustafa E M Radwan; Nagham M Mahmoud; Omar M Herdan; Khalid A Mohamad; Sherifa A Hamed Journal: Rheumatol Int Date: 2012-10-12 Impact factor: 2.631
Authors: César Magro Checa; Danielle Cohen; Eduard L E M Bollen; Mark A van Buchem; Tom W J Huizinga; Gerda M Steup-Beekman Journal: Best Pract Res Clin Rheumatol Date: 2013-06 Impact factor: 4.098
Authors: Stephen M Smith; Mark Jenkinson; Heidi Johansen-Berg; Daniel Rueckert; Thomas E Nichols; Clare E Mackay; Kate E Watkins; Olga Ciccarelli; M Zaheer Cader; Paul M Matthews; Timothy E J Behrens Journal: Neuroimage Date: 2006-04-19 Impact factor: 6.556
Authors: Rex E Jung; Robert S Chavez; Ranee A Flores; Clifford Qualls; Wilmer L Sibbitt; Carlos A Roldan Journal: PLoS One Date: 2012-01-26 Impact factor: 3.240
Authors: Diogo G Corrêa; Nicolle Zimmermann; Rafael S Borges; Denis B Pereira; Thomas M Doring; Gustavo Tukamoto; Rochele P Fonseca; Emerson L Gasparetto Journal: Neuroradiol J Date: 2018-08-09