Zhong Zheng Jia1, Hong Mei Gu2, Xue Jun Zhou3, Jin Long Shi4, Min Da Li5, Guo Feng Zhou6, Xian Hua Wu7. 1. Department of Radiology, Affiliated Hospital of Nantong University, 20 Xisi Road Nantong, 226001 Jiangsu, PR China. Electronic address: jzz2397@163.com. 2. Department of Radiology, Affiliated Hospital of Nantong University, 20 Xisi Road Nantong, 226001 Jiangsu, PR China. Electronic address: guhongmei71@163.com. 3. Department of Radiology, Affiliated Hospital of Nantong University, 20 Xisi Road Nantong, 226001 Jiangsu, PR China. Electronic address: zxj0925101@sina.com. 4. Department of Neurosurgery, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong 226001, Jiangsu, PR China. Electronic address: shij_ns@163.com. 5. Department of Radiology, Affiliated Hospital of Nantong University, 20 Xisi Road Nantong, 226001 Jiangsu, PR China. Electronic address: 115218103@qq.com. 6. Department of Radiology, Affiliated Hospital of Nantong University, 20 Xisi Road Nantong, 226001 Jiangsu, PR China. Electronic address: 292768853@qq.com. 7. Department of Radiology, Affiliated Hospital of Nantong University, 20 Xisi Road Nantong, 226001 Jiangsu, PR China. Electronic address: wuxianhua58@sohu.com.
Abstract
PURPOSE: This study was designed to quantitatively evaluate the immature microvascular density (MVD) of brain gliomas using the volume transfer constant (K(trans)) and volume of extravascular extracellular space per unit volume of tissue (Ve) from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) noninvasively. MATERIALS AND METHODS: Fifty-seven patients (35 males, 22 females; age range, 14-70, mean age 46±12 years old) with brain glioma were included in this study. The maximal values of K(trans) and Ve of all patients with brain glioma (grade II 24, III 7 and IV 26) were obtained. The CD105-microvascular density (CD105-MVD) of each tumor was measured in surgical specimen. The differences of K(trans), Ve and CD105-MVD between the different grades of gliomas were analyzed using the Mann-Whitney U-test. The Pearman correlation coefficient was determined between K(trans), Ve and CD105-MVD. A P-value of less than 0.05 was considered statistically significant. RESULTS: The differences in K(trans), Ve and CD105-MVD were statistically significant between low-grade glioma (LGG) and high-grade glioma (HGG) (P=0.001, P<0.001, P<0.001). The K(trans), Ve and CD105-MVD of grade II were significantly lower than those of grade III and IV. K(trans) and Ve were positively correlated with CD105-MVD in HGG (P<0.001, P<0.001). CONCLUSIONS: Our results suggest DCE-MRI plays an important part in noninvasively evaluating the immature MVD of brain gliomas.
PURPOSE: This study was designed to quantitatively evaluate the immature microvascular density (MVD) of brain gliomas using the volume transfer constant (K(trans)) and volume of extravascular extracellular space per unit volume of tissue (Ve) from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) noninvasively. MATERIALS AND METHODS: Fifty-seven patients (35 males, 22 females; age range, 14-70, mean age 46±12 years old) with brain glioma were included in this study. The maximal values of K(trans) and Ve of all patients with brain glioma (grade II 24, III 7 and IV 26) were obtained. The CD105-microvascular density (CD105-MVD) of each tumor was measured in surgical specimen. The differences of K(trans), Ve and CD105-MVD between the different grades of gliomas were analyzed using the Mann-Whitney U-test. The Pearman correlation coefficient was determined between K(trans), Ve and CD105-MVD. A P-value of less than 0.05 was considered statistically significant. RESULTS: The differences in K(trans), Ve and CD105-MVD were statistically significant between low-grade glioma (LGG) and high-grade glioma (HGG) (P=0.001, P<0.001, P<0.001). The K(trans), Ve and CD105-MVD of grade II were significantly lower than those of grade III and IV. K(trans) and Ve were positively correlated with CD105-MVD in HGG (P<0.001, P<0.001). CONCLUSIONS: Our results suggest DCE-MRI plays an important part in noninvasively evaluating the immature MVD of brain gliomas.
Authors: Vera C Keil; Bogdan Pintea; Gerrit H Gielen; Susanne Greschus; Rolf Fimmers; Jürgen Gieseke; Matthias Simon; Hans H Schild; Dariusch R Hadizadeh Journal: J Neurooncol Date: 2017-04-19 Impact factor: 4.130
Authors: Alexey Surov; Hans Jonas Meyer; Matthias Gawlitza; Anne-Kathrin Höhn; Andreas Boehm; Thomas Kahn; Patrick Stumpp Journal: Transl Oncol Date: 2016-11-24 Impact factor: 4.243
Authors: Hans Jonas Meyer; Leonard Leifels; Gordian Hamerla; Anne Kathrin Höhn; Alexey Surov Journal: Contrast Media Mol Imaging Date: 2019-01-02 Impact factor: 3.161
Authors: S J Mills; D du Plessis; P Pal; G Thompson; G Buonacorrsi; C Soh; G J M Parker; A Jackson Journal: AJNR Am J Neuroradiol Date: 2015-12-24 Impact factor: 3.825