Literature DB >> 27876535

4-hydroxynonenal-mediated signaling and aging.

Hongqiao Zhang1, Henry Jay Forman2.   

Abstract

4-Hydroxy-2-nonenal (HNE), one of the major α, β-unsaturated aldehydes produced during lipid peroxidation, is a potent messenger in mediating signaling pathways. Lipid peroxidation and HNE production appear to increase with aging. Although the cause and effect relation remains arguable, aging is associated with significant changes in diverse signaling events, characterized by enhanced or diminished responses of specific signaling pathways. In this review we will discuss how HNE may contribute to aging-related alterations of signaling pathways.
Copyright © 2017 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  4-Hydroxynoneal; Aging; HNE; Oxidative stress; Redox signaling

Mesh：

Substances：

Year:  2016        PMID： 27876535      PMCID： PMC5438786          DOI： 10.1016/j.freeradbiomed.2016.11.032

Source DB:  PubMed          Journal:  Free Radic Biol Med        ISSN： 0891-5849            Impact factor:   7.376


  121 in total

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Authors:  D HARMAN
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Review 4.  Lipid peroxidation and neurodegenerative disease.

Authors:  Tanea T Reed
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Review 6.  Oxidized LDL and 4-hydroxynonenal modulate tyrosine kinase receptor activity.

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Review 8.  Protein modification by oxidized phospholipids and hydrolytically released lipid electrophiles: Investigating cellular responses.

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Journal:  Redox Biol       Date:  2016-01-19       Impact factor: 11.799
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Review 4.  Is carbonyl/AGE/RAGE stress a hallmark of the brain aging?

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6.  Nuclear Sphingosine-1-phosphate Lyase Generated ∆2-hexadecenal is A Regulator of HDAC Activity and Chromatin Remodeling in Lung Epithelial Cells.

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Review 7.  Lipid (per) oxidation in mitochondria: an emerging target in the ageing process?

Authors:  O S Ademowo; H K I Dias; D G A Burton; H R Griffiths
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Review 8.  Reactive oxygen species (ROS) as pleiotropic physiological signalling agents.

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Review 9.  Antioxidant Therapeutic Strategies for Cardiovascular Conditions Associated with Oxidative Stress.

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Review 10.  Origin and pathophysiology of protein carbonylation, nitration and chlorination in age-related brain diseases and aging.

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