Literature DB >> 2606483

Use of transgenic mice for the characterization of human alpha 1-acid glycoprotein (orosomucoid) variants.

L Tomei1, C B Eap, P Baumann, L Dente.   

Abstract

Sera from transgenic mice (TM) carrying human genes of alpha 1-acid glycoprotein (orosomucoid or ORM) have been analyzed by isoelectrofocusing and subsequent immunoblotting with antihuman ORM antibodies. With this technique it is possible to reveal selectively the human protein secreted in the TM sera. Orosomucoid bands present in TM sera have been compared with those of the most common human ORM phenotypes to correlate the products of specific genes to previously identified genetic variants. In this paper, we report the identification of the genes encoding for variants ORM1 F1 and ORM2 A, which are genes AGP-A and AGP-B/B' respectively. The nucleotide sequences of these genes are known; therefore a direct correlation between variants and specific amino acid sequences can be established.

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Year:  1989        PMID： 2606483     DOI： 10.1007/bf00210681

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  10 in total

1.  Expression of human alpha 1-acid glycoprotein genes in cultured cells and in transgenic mice.

Authors:  L Dente; U Rüther; M Tripodi; E F Wagner; R Cortese
Journal:  Genes Dev       Date:  1988-02       Impact factor: 11.361

2.  Mapping through somatic cell hybrids and cDNA probes of protein C to chromosome 2, factor X to chromosome 13, and alpha 1-acid glycoprotein to chromosome 9.

Authors:  M Rocchi; L Roncuzzi; R Santamaria; N Archidiacono; L Dente; G Romeo
Journal:  Hum Genet       Date:  1986-09       Impact factor: 4.132

3.  Isoelectric focusing of alpha-1 acid glycoprotein (orosomucoid) in immobilized pH-gradients with 8M urea: detection of its desialylated variants using an alkaline phosphatase-linked secondary antibody system.

Authors:  C B Eap; P Baumann
Journal:  Electrophoresis       Date:  1988-10       Impact factor: 3.535

4.  The amino acid substitutions found in the genetic variants of 1 -acid glycoprotein.

Authors:  R Nimberg; T Motoyama; K Schmid
Journal:  J Biol Chem       Date:  1971-09-25       Impact factor: 5.157

Review 5.  Germ-line transformation of mice.

Authors:  R D Palmiter; R L Brinster
Journal:  Annu Rev Genet       Date:  1986       Impact factor: 16.830

6.  Inheritance of human alpha-1-acid glycoprotein (orosomucoid) variants.

Authors:  A M Johnson; K Schmid; C A Alper
Journal:  J Clin Invest       Date:  1969-12       Impact factor: 14.808

7.  Three new orosomucoid (ORM) variants revealed by isoelectric focusing and print immunofixation.

Authors:  S Weidinger; T Müller; F Schwarzfischer; H Cleve
Journal:  Hum Genet       Date:  1987-11       Impact factor: 4.132

8.  Direct assignment of orosomucoid to human chromosome 9 and alpha 2HS-glycoprotein to chromosome 3 using human fetal liver x rat hepatoma hybrids.

Authors:  D W Cox; U Francke
Journal:  Hum Genet       Date:  1985       Impact factor: 4.132

9.  Orosomucoid (ORM) typing by isoelectric focusing: evidence of two structural loci ORM1 and ORM2.

Authors:  I Yuasa; K Umetsu; K Suenaga; M Robinet-Levy
Journal:  Hum Genet       Date:  1986-10       Impact factor: 4.132

10.  Structure and expression of the genes coding for human alpha 1-acid glycoprotein.

Authors:  L Dente; M G Pizza; A Metspalu; R Cortese
Journal:  EMBO J       Date:  1987-08       Impact factor: 11.598
  10 in total
  7 in total

1.  Role of biantennary glycans and genetic variants of human alpha1-acid glycoprotein in enantioselective binding of basic drugs as studied by high performance frontal analysis/capillary electrophoresis.

Authors:  Y Kuroda; Y Kita; A Shibukawa; T Nakagawa
Journal:  Pharm Res       Date:  2001-03       Impact factor: 4.200

2.  Inflammation-induced changes in expression and glycosylation of genetic variants of alpha 1-acid glycoprotein. Studies with human sera, primary cultures of human hepatocytes and transgenic mice.

Authors:  W van Dijk; O Pos; M E van der Stelt; H J Moshage; S H Yap; L Dente; P Baumann; C B Eap
Journal:  Biochem J       Date:  1991-06-01       Impact factor: 3.857

Review 3.  Interindividual variability of the clinical pharmacokinetics of methadone: implications for the treatment of opioid dependence.

Authors:  Chin B Eap; Thierry Buclin; Pierre Baumann
Journal:  Clin Pharmacokinet       Date:  2002       Impact factor: 6.447

4.  Biantennary glycans as well as genetic variants of alpha1-acid glycoprotein control the enantioselectivity and binding affinity of oxybutynin.

Authors:  Tomoko Kimura; Akimasa Shibukawa; Katsumi Matsuzaki
Journal:  Pharm Res       Date:  2006-05-02       Impact factor: 4.200

5.  Evidence for differences in the binding of drugs to the two main genetic variants of human alpha 1-acid glycoprotein.

Authors:  F Herve; E Gomas; J C Duche; J P Tillement
Journal:  Br J Clin Pharmacol       Date:  1993-09       Impact factor: 4.335

6.  Differential binding of disopyramide and warfarin enantiomers to human alpha(1)-acid glycoprotein variants.

Authors:  T Nakagawa; S Kishino; S Itoh; M Sugawara; K Miyazaki
Journal:  Br J Clin Pharmacol       Date:  2003-12       Impact factor: 4.335

7.  Implications of plasma protein binding for pharmacokinetics and pharmacodynamics of the γ-secretase inhibitor RO4929097.

Authors:  Jianmei Wu; Patricia M Lorusso; Larry H Matherly; Jing Li
Journal:  Clin Cancer Res       Date:  2012-02-20       Impact factor: 12.531
  7 in total

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